Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210261785> ?p ?o ?g. }
- W4210261785 endingPage "2101004" @default.
- W4210261785 startingPage "2101004" @default.
- W4210261785 abstract "Scope: Garlic is a source of bioactive phytonutrients that may have anti-inflammatory or immunomodulatory properties. The mechanism(s) underlying the bioactivity of these compounds and their ability to regulate responses to enteric infections remains unclear. Methods and Results: This study investigates if a garlic-derived preparation (PTSO-PTS) containing two organosulfur metabolites, propyl-propane thiosulfonate (PTSO), and propyl-propane thiosulfinate (PTS), regulate inflammatory responses in murine macrophages and intestinal epithelial cells (IEC) in vitro, as well as in a model of enteric parasite-induced inflammation. PTSO-PTS decreases lipopolysaccharide-induced secretion of TNFα, IL-6, and IL-27 in macrophages. RNA-sequencing demonstrates that PTSO-PTS strongly suppresses pathways related to immune and inflammatory signaling. PTSO-PTS induces the expression of a number of genes involved in antioxidant responses in IEC during exposure to antigens from the parasite Trichuris muris. In vivo, PTSO-PTS does not affect T. muris establishment or intestinal T-cell responses but significantly alters cecal transcriptomic responses. Notably, a reduction in T. muris-induced expression of Tnf, Saa2, and Nos2 is observed. Conclusion: Garlic-derived organosulfur compounds exert anti-inflammatory effects in macrophages and IEC, and regulate gene expression during intestinal infection. These compounds and related organic molecules may thus hold potential as functional food components to improve gut health in humans and animals." @default.
- W4210261785 created "2022-02-08" @default.
- W4210261785 creator A5007856244 @default.
- W4210261785 creator A5009876003 @default.
- W4210261785 creator A5011135647 @default.
- W4210261785 creator A5012943086 @default.
- W4210261785 creator A5029448913 @default.
- W4210261785 creator A5082344657 @default.
- W4210261785 date "2022-03-07" @default.
- W4210261785 modified "2023-10-16" @default.
- W4210261785 title "Garlic‐Derived Organosulfur Compounds Regulate Metabolic and Immune Pathways in Macrophages and Attenuate Intestinal Inflammation in Mice" @default.
- W4210261785 cites W1482193400 @default.
- W4210261785 cites W1591556006 @default.
- W4210261785 cites W1617495083 @default.
- W4210261785 cites W1764616085 @default.
- W4210261785 cites W1805101691 @default.
- W4210261785 cites W1980139558 @default.
- W4210261785 cites W1986974750 @default.
- W4210261785 cites W1988284899 @default.
- W4210261785 cites W1989040902 @default.
- W4210261785 cites W1994087706 @default.
- W4210261785 cites W1994516121 @default.
- W4210261785 cites W1996715522 @default.
- W4210261785 cites W2000590947 @default.
- W4210261785 cites W2001312881 @default.
- W4210261785 cites W2003638783 @default.
- W4210261785 cites W2004021775 @default.
- W4210261785 cites W2013888332 @default.
- W4210261785 cites W2027709526 @default.
- W4210261785 cites W2032848765 @default.
- W4210261785 cites W2033107127 @default.
- W4210261785 cites W2040761834 @default.
- W4210261785 cites W2049356233 @default.
- W4210261785 cites W2049727721 @default.
- W4210261785 cites W2056804078 @default.
- W4210261785 cites W2071524497 @default.
- W4210261785 cites W2075123115 @default.
- W4210261785 cites W2076644494 @default.
- W4210261785 cites W2096715073 @default.
- W4210261785 cites W2097993964 @default.
- W4210261785 cites W2105335085 @default.
- W4210261785 cites W2120214848 @default.
- W4210261785 cites W2121902138 @default.
- W4210261785 cites W2142827416 @default.
- W4210261785 cites W2148758723 @default.
- W4210261785 cites W2155187925 @default.
- W4210261785 cites W2166342119 @default.
- W4210261785 cites W2179438025 @default.
- W4210261785 cites W2192476739 @default.
- W4210261785 cites W2207203390 @default.
- W4210261785 cites W2234649706 @default.
- W4210261785 cites W2327271215 @default.
- W4210261785 cites W2345765779 @default.
- W4210261785 cites W2525337111 @default.
- W4210261785 cites W2530777283 @default.
- W4210261785 cites W2590599688 @default.
- W4210261785 cites W2616566208 @default.
- W4210261785 cites W2725542392 @default.
- W4210261785 cites W2769499994 @default.
- W4210261785 cites W2889183502 @default.
- W4210261785 cites W2890410496 @default.
- W4210261785 cites W2903101144 @default.
- W4210261785 cites W2944125141 @default.
- W4210261785 cites W2945040241 @default.
- W4210261785 cites W2982635577 @default.
- W4210261785 cites W2983483442 @default.
- W4210261785 cites W2998155999 @default.
- W4210261785 cites W3006313428 @default.
- W4210261785 cites W3015245383 @default.
- W4210261785 cites W3045801639 @default.
- W4210261785 cites W3109082402 @default.
- W4210261785 cites W3115484443 @default.
- W4210261785 cites W3137496383 @default.
- W4210261785 cites W3179171351 @default.
- W4210261785 cites W3184836035 @default.
- W4210261785 cites W4205646352 @default.
- W4210261785 cites W4210261785 @default.
- W4210261785 doi "https://doi.org/10.1002/mnfr.202101004" @default.
- W4210261785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35107883" @default.
- W4210261785 hasPublicationYear "2022" @default.
- W4210261785 type Work @default.
- W4210261785 citedByCount "9" @default.
- W4210261785 countsByYear W42102617852022 @default.
- W4210261785 countsByYear W42102617852023 @default.
- W4210261785 crossrefType "journal-article" @default.
- W4210261785 hasAuthorship W4210261785A5007856244 @default.
- W4210261785 hasAuthorship W4210261785A5009876003 @default.
- W4210261785 hasAuthorship W4210261785A5011135647 @default.
- W4210261785 hasAuthorship W4210261785A5012943086 @default.
- W4210261785 hasAuthorship W4210261785A5029448913 @default.
- W4210261785 hasAuthorship W4210261785A5082344657 @default.
- W4210261785 hasBestOaLocation W42102617852 @default.
- W4210261785 hasConcept C150903083 @default.
- W4210261785 hasConcept C178790620 @default.
- W4210261785 hasConcept C185592680 @default.
- W4210261785 hasConcept C203014093 @default.
- W4210261785 hasConcept C207001950 @default.
- W4210261785 hasConcept C25366896 @default.