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- W4210265450 endingPage "281" @default.
- W4210265450 startingPage "281" @default.
- W4210265450 abstract "Oomycetes, of the genus Phytophthora, comprise of some of the most devastating plant pathogens. Parasitism of Phytophthora results from evolution from an autotrophic ancestor and adaptation to a wide range of environments, involving metabolic adaptation. Sequence mining showed that Phytophthora spp. display an unusual repertoire of glycolytic enzymes, made of multigene families and enzyme replacements. To investigate the impact of these gene duplications on the biology of Phytophthora and, eventually, identify novel functions associated to gene expansion, we focused our study on the first glycolytic step on P. nicotianae, a broad host range pathogen. We reveal that this step is committed by a set of three glucokinase types that differ by their structure, enzymatic properties, and evolutionary histories. In addition, they are expressed differentially during the P. nicotianae life cycle, including plant infection. Last, we show that there is a strong association between the expression of a glucokinase member in planta and extent of plant infection. Together, these results suggest that metabolic adaptation is a component of the processes underlying evolution of parasitism in Phytophthora, which may possibly involve the neofunctionalization of metabolic enzymes." @default.
- W4210265450 created "2022-02-08" @default.
- W4210265450 creator A5015528739 @default.
- W4210265450 creator A5033903813 @default.
- W4210265450 creator A5067479563 @default.
- W4210265450 creator A5086280209 @default.
- W4210265450 date "2022-01-25" @default.
- W4210265450 modified "2023-10-18" @default.
- W4210265450 title "Neofunctionalization of Glycolytic Enzymes: An Evolutionary Route to Plant Parasitism in the Oomycete Phytophthora nicotianae" @default.
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