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- W4210270040 abstract "A network of coupled promoting motions in the enzyme dihydrofolate reductase is identified and characterized. The present identification is based on genomic analysis for sequence conservation, kinetic measurements of multiple mutations, and mixed quantum/classical molecular dynamics simulations of hydride transfer. The motions in this network span time scales of femtoseconds to milliseconds and are found on the exterior of the enzyme as well as in the active site. This type of network has broad implications for an expanded role of the protein fold in catalysis as well as ancillaries such as the engineering of altered protein function and the action of drugs distal to the active site. PMID: 11867722 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R37 GM024129 NIGMS NIH HHS, United States Grant ID: R01 GM024129 NIGMS NIH HHS, United States Grant ID: R01 GM056207 NIGMS NIH HHS, United States Grant ID: GM56207 NIGMS NIH HHS, United States Grant ID: R37 GM056207 NIGMS NIH HHS, United States Grant ID: GM24129 More Less keyboard_arrow_down" @default.
- W4210270040 created "2022-02-08" @default.
- W4210270040 creator A5068399282 @default.
- W4210270040 date "2002-11-03" @default.
- W4210270040 modified "2023-10-16" @default.
- W4210270040 title "Faculty Opinions recommendation of Network of coupled promoting motions in enzyme catalysis." @default.
- W4210270040 doi "https://doi.org/10.3410/f.1004445.149058" @default.
- W4210270040 hasPublicationYear "2002" @default.
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