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- W4210270307 endingPage "105" @default.
- W4210270307 startingPage "105" @default.
- W4210270307 abstract "Advances in sequencing technologies have facilitated the discovery of previously unknown genetic variants in both inherited and acquired disorders, and tools to correct these pathogenic variants are rapidly evolving. Since the first introduction of CRISPR-Cas9 in 2012, the field of CRISPR-based genome editing has progressed immensely, giving hope to many patients suffering from genetic disorders that lack effective treatment. In this review, we will examine the basic principles of CRISPR-based genome editing, explain the mechanisms of new genome editors, including base editors and prime editors, and evaluate the therapeutic possibilities of CRISPR-based genome editing by focusing on recently published clinical trials and animal studies. Although efficacy and safety issues remain a large concern, we cannot deny that CRISPR-based genome editing will soon be prevalent in clinical practice." @default.
- W4210270307 created "2022-02-08" @default.
- W4210270307 creator A5005350761 @default.
- W4210270307 creator A5019048819 @default.
- W4210270307 date "2022-01-01" @default.
- W4210270307 modified "2023-10-15" @default.
- W4210270307 title "Basic Principles and Clinical Applications of CRISPR-Based Genome Editing" @default.
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- W4210270307 doi "https://doi.org/10.3349/ymj.2022.63.2.105" @default.
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