FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210270335> ?p ?o ?g. }

• W4210270335 abstract "Abstract Background Almost two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted, nor new tests identified to improve the prediction and management of SARS-CoV-2 infection. Methods Retrospective observational analysis of the predictive performance of clinical parameters and laboratory tests in hospitalised patients with COVID-19. Outcomes were 28-day survival and maximal severity in a cohort of 1,579 patients and two validation cohorts of 598 and 434 patients. A pilot study conducted in a patient subgroup measured 17 cytokines and 27 lymphocyte phenotypes to explore additional predictive laboratory tests. Findings 1) Despite a strong association of 22 clinical and laboratory variables with the outcomes, their joint prediction power was limited due to redundancy. 2) Eight variables: age, comorbidity index, oxygen saturation to fraction of inspired oxygen ratio, neutrophil-lymphocyte ratio, C- reactive protein, aspartate aminotransferase/alanine aminotransferase ratio, fibrinogen, and glomerular filtration rate captured most of the statistical predictive power. 3) The interpretation of clinical and laboratory variables was improved by grouping them in categories. 4) Age and organ damage-related tests were the best predictors of survival, and inflammatory-related tests were the best predictors of severity. 5) The pilot study identified several immunological tests (including chemokine ligand 10, chemokine ligand 2, and interleukin 1 receptor antagonist), that performed better than currently used tests. Conclusions Currently used tests for clinical management of COVID-19 patients are of limited value due to redundancy, as all measure aspects of two major processes: inflammation, and organ damage. There are no independent predictors based on the quality of the nascent adaptive immune response. Understanding the limitations of current tests would improve their interpretation and simplify clinical management protocols. A systematic search for better biomarkers is urgent and feasible." @default.
• W4210270335 created "2022-02-08" @default.
• W4210270335 creator A5005681186 @default.
• W4210270335 creator A5008359527 @default.
• W4210270335 creator A5012692341 @default.
• W4210270335 creator A5018817468 @default.
• W4210270335 creator A5039607526 @default.
• W4210270335 creator A5040115266 @default.
• W4210270335 creator A5043324785 @default.
• W4210270335 creator A5055081223 @default.
• W4210270335 creator A5058669821 @default.
• W4210270335 creator A5059651140 @default.
• W4210270335 creator A5062104207 @default.
• W4210270335 creator A5065210724 @default.
• W4210270335 creator A5065415092 @default.
• W4210270335 creator A5070663244 @default.
• W4210270335 creator A5070703120 @default.
• W4210270335 creator A5071067623 @default.
• W4210270335 creator A5071119719 @default.
• W4210270335 creator A5074190689 @default.
• W4210270335 creator A5077297965 @default.
• W4210270335 creator A5077547848 @default.
• W4210270335 creator A5082838652 @default.
• W4210270335 creator A5086285959 @default.
• W4210270335 creator A5091705909 @default.
• W4210270335 creator A9999999999 @default.
• W4210270335 date "2022-02-02" @default.
• W4210270335 modified "2023-10-18" @default.
• W4210270335 title "Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters" @default.
• W4210270335 cites W1965827638 @default.
• W4210270335 cites W2078271269 @default.
• W4210270335 cites W2150979970 @default.
• W4210270335 cites W2155965977 @default.
• W4210270335 cites W2891159041 @default.
• W4210270335 cites W2897796957 @default.
• W4210270335 cites W3009885589 @default.
• W4210270335 cites W3014524604 @default.
• W4210270335 cites W3034168389 @default.
• W4210270335 cites W3034219882 @default.
• W4210270335 cites W3034858522 @default.
• W4210270335 cites W3036779511 @default.
• W4210270335 cites W3039901154 @default.
• W4210270335 cites W3040959680 @default.
• W4210270335 cites W3041424063 @default.
• W4210270335 cites W3041494167 @default.
• W4210270335 cites W3041960835 @default.
• W4210270335 cites W3042587425 @default.
• W4210270335 cites W3043400019 @default.
• W4210270335 cites W3043831218 @default.
• W4210270335 cites W3046194290 @default.
• W4210270335 cites W3046629770 @default.
• W4210270335 cites W3047880178 @default.
• W4210270335 cites W3048742086 @default.
• W4210270335 cites W3084166920 @default.
• W4210270335 cites W3085989258 @default.
• W4210270335 cites W3087855548 @default.
• W4210270335 cites W3087862874 @default.
• W4210270335 cites W3091337946 @default.
• W4210270335 cites W3105918023 @default.
• W4210270335 cites W3107765474 @default.
• W4210270335 cites W3111459703 @default.
• W4210270335 cites W3116936469 @default.
• W4210270335 cites W3119858919 @default.
• W4210270335 cites W3127095101 @default.
• W4210270335 cites W3130409179 @default.
• W4210270335 cites W3159073875 @default.
• W4210270335 cites W3160218882 @default.
• W4210270335 cites W3182807823 @default.
• W4210270335 cites W3186439913 @default.
• W4210270335 cites W3212812295 @default.
• W4210270335 doi "https://doi.org/10.1101/2022.01.29.22270016" @default.
• W4210270335 hasPublicationYear "2022" @default.
• W4210270335 type Work @default.
• W4210270335 citedByCount "0" @default.
• W4210270335 crossrefType "posted-content" @default.
• W4210270335 hasAuthorship W4210270335A5005681186 @default.
• W4210270335 hasAuthorship W4210270335A5008359527 @default.
• W4210270335 hasAuthorship W4210270335A5012692341 @default.
• W4210270335 hasAuthorship W4210270335A5018817468 @default.
• W4210270335 hasAuthorship W4210270335A5039607526 @default.
• W4210270335 hasAuthorship W4210270335A5040115266 @default.
• W4210270335 hasAuthorship W4210270335A5043324785 @default.
• W4210270335 hasAuthorship W4210270335A5055081223 @default.
• W4210270335 hasAuthorship W4210270335A5058669821 @default.
• W4210270335 hasAuthorship W4210270335A5059651140 @default.
• W4210270335 hasAuthorship W4210270335A5062104207 @default.
• W4210270335 hasAuthorship W4210270335A5065210724 @default.
• W4210270335 hasAuthorship W4210270335A5065415092 @default.
• W4210270335 hasAuthorship W4210270335A5070663244 @default.
• W4210270335 hasAuthorship W4210270335A5070703120 @default.
• W4210270335 hasAuthorship W4210270335A5071067623 @default.
• W4210270335 hasAuthorship W4210270335A5071119719 @default.
• W4210270335 hasAuthorship W4210270335A5074190689 @default.
• W4210270335 hasAuthorship W4210270335A5077297965 @default.
• W4210270335 hasAuthorship W4210270335A5077547848 @default.
• W4210270335 hasAuthorship W4210270335A5082838652 @default.
• W4210270335 hasAuthorship W4210270335A5086285959 @default.
• W4210270335 hasAuthorship W4210270335A5091705909 @default.
• W4210270335 hasAuthorship W4210270335A9999999999 @default.
• W4210270335 hasBestOaLocation W42102703351 @default.

• next