FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210272303> ?p ?o ?g. }

• W4210272303 endingPage "173" @default.
• W4210272303 startingPage "173" @default.
• W4210272303 abstract "The current antimicrobial therapy of bacterial infections of the central nervous system (CNS) in adults and pediatric patients is faced with many pitfalls as the drugs have to reach necessary levels in serum and cross the blood-brain barrier. Furthermore, several studies report that different factors such as the structure of the antimicrobial agent, the severity of disease, or the degree of inflammation play a significant role. Despite the available attempts to establish pharmacokinetic (PK) modeling to improve the required dosing regimen for adults and pediatric patients, conclusive recommendations for the best therapeutic strategies are still lacking. For instance, bacterial meningitis, the most common CNS infections, and ventriculitis, a severe complication of meningitis, are still associated with 10% and 30% mortality, respectively. Several studies report on the use of vancomycin and meropenem to manage meningitis and ventriculitis; therefore, this review aims to shed light on the current knowledge about their use in adults and pediatric patients. Consequently, studies published from 2015 until mid-July 2021 are included, and data about the study population, levels of drugs in serum and cerebrospinal fluid (CSF), and measured PK data in serum and CSF are provided. The overall aim is to provide the readers a recent reference that summarizes the pitfalls and success of the current therapy and emphasizes the importance of performing more studies to improve the clinical outcome of the current therapeutical approach." @default.
• W4210272303 created "2022-02-08" @default.
• W4210272303 creator A5007358380 @default.
• W4210272303 creator A5054344760 @default.
• W4210272303 creator A5056518653 @default.
• W4210272303 date "2022-01-28" @default.
• W4210272303 modified "2023-10-03" @default.
• W4210272303 title "Efficacy of Vancomycin and Meropenem in Central Nervous System Infections in Children and Adults: Current Update" @default.
• W4210272303 cites W1508155772 @default.
• W4210272303 cites W1993045657 @default.
• W4210272303 cites W1995208533 @default.
• W4210272303 cites W2008055081 @default.
• W4210272303 cites W2009450226 @default.
• W4210272303 cites W2010587136 @default.
• W4210272303 cites W2018115918 @default.
• W4210272303 cites W2027143209 @default.
• W4210272303 cites W2042135416 @default.
• W4210272303 cites W2063680844 @default.
• W4210272303 cites W2065254807 @default.
• W4210272303 cites W2087456839 @default.
• W4210272303 cites W2094377223 @default.
• W4210272303 cites W2106209372 @default.
• W4210272303 cites W2109178387 @default.
• W4210272303 cites W2140147718 @default.
• W4210272303 cites W2140603169 @default.
• W4210272303 cites W2169527394 @default.
• W4210272303 cites W2330000605 @default.
• W4210272303 cites W2333702729 @default.
• W4210272303 cites W2339844999 @default.
• W4210272303 cites W2509207472 @default.
• W4210272303 cites W2510746161 @default.
• W4210272303 cites W2520529239 @default.
• W4210272303 cites W2538481234 @default.
• W4210272303 cites W2550030526 @default.
• W4210272303 cites W2563915997 @default.
• W4210272303 cites W2588163058 @default.
• W4210272303 cites W2615999950 @default.
• W4210272303 cites W2621581718 @default.
• W4210272303 cites W2738843885 @default.
• W4210272303 cites W2750536926 @default.
• W4210272303 cites W2755661725 @default.
• W4210272303 cites W2760678255 @default.
• W4210272303 cites W2766091818 @default.
• W4210272303 cites W2781776119 @default.
• W4210272303 cites W2786832455 @default.
• W4210272303 cites W2799458343 @default.
• W4210272303 cites W2800525519 @default.
• W4210272303 cites W2803255010 @default.
• W4210272303 cites W2806467564 @default.
• W4210272303 cites W2829019739 @default.
• W4210272303 cites W2886881481 @default.
• W4210272303 cites W2891344774 @default.
• W4210272303 cites W2892958770 @default.
• W4210272303 cites W2898503217 @default.
• W4210272303 cites W2900422322 @default.
• W4210272303 cites W2911628008 @default.
• W4210272303 cites W2913489687 @default.
• W4210272303 cites W2949613766 @default.
• W4210272303 cites W3013010105 @default.
• W4210272303 cites W3021874111 @default.
• W4210272303 cites W3100508550 @default.
• W4210272303 cites W3103735613 @default.
• W4210272303 cites W3138820854 @default.
• W4210272303 cites W3157754021 @default.
• W4210272303 cites W3189216058 @default.
• W4210272303 cites W2954496304 @default.
• W4210272303 doi "https://doi.org/10.3390/antibiotics11020173" @default.
• W4210272303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203776" @default.
• W4210272303 hasPublicationYear "2022" @default.
• W4210272303 type Work @default.
• W4210272303 citedByCount "16" @default.
• W4210272303 countsByYear W42102723032022 @default.
• W4210272303 countsByYear W42102723032023 @default.
• W4210272303 crossrefType "journal-article" @default.
• W4210272303 hasAuthorship W4210272303A5007358380 @default.
• W4210272303 hasAuthorship W4210272303A5054344760 @default.
• W4210272303 hasAuthorship W4210272303A5056518653 @default.
• W4210272303 hasBestOaLocation W42102723031 @default.
• W4210272303 hasConcept C126322002 @default.
• W4210272303 hasConcept C177713679 @default.
• W4210272303 hasConcept C178790620 @default.
• W4210272303 hasConcept C185592680 @default.
• W4210272303 hasConcept C187212893 @default.
• W4210272303 hasConcept C2777288759 @default.
• W4210272303 hasConcept C2778980435 @default.
• W4210272303 hasConcept C2779375183 @default.
• W4210272303 hasConcept C2779489039 @default.
• W4210272303 hasConcept C2779862588 @default.
• W4210272303 hasConcept C2781026528 @default.
• W4210272303 hasConcept C2908647359 @default.
• W4210272303 hasConcept C4937899 @default.
• W4210272303 hasConcept C501593827 @default.
• W4210272303 hasConcept C523546767 @default.
• W4210272303 hasConcept C54355233 @default.
• W4210272303 hasConcept C71924100 @default.
• W4210272303 hasConcept C86803240 @default.
• W4210272303 hasConcept C89423630 @default.
• W4210272303 hasConcept C94665300 @default.

• next