FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210274744> ?p ?o ?g. }

• W4210274744 abstract "Acute lung injury (ALI) is characterized by the abrupt onset of clinically significant hypoxemia in the context of non-hydrostatic pulmonary edema. Acute lung injury is associated with cytokine release and plasma extravasation (PEx) that can cause pulmonary edema and subsequently acute respiratory distress syndrome (ARDS). Therefore, it is critical we understand the relationship between ALI and lung PEx. In addition, it is also important to assess PEx in the lungs and other organs post-ALI since ALI/ARDS often causes multi-organ failure. We hypothesized that ALI induces time-dependent lung PEx, which promotes extravasation in the heart, liver, kidney, spleen, pancreas, and gastrointestinal (GI) tract, in a time-dependent manner. To test our hypothesis, we administered bleomycin or saline via tracheal intubation in 8-week-old Sprague Dawley rats. At the terminal experiments, Evans Blue was injected (IV) through the femoral vein to allow for the visualization of PEx. Plasma extravasation of desired organs was evaluated at 3-, 7-, 14-, 21-, and 28-days after bleomycin or saline treatment by evaluating Evans Blue concentrations calorimetrically at fluorescence excitation wavelength of 620 nm (bandwidth 10 nm) and an emission wavelength of 680 nm (bandwidth 40 nm). Data show that ALI induces lung PEx beginning at day 3 and peaking between 7 and 21 days. Extravasation was also seen in all organs at varying degrees beginning at day 3 and peaking between days 7 and 14. Resolution appears to start after day 21 and continues past day 28. We conclude that ALI caused by bleomycin incites a time-dependent PEx of the lungs and multiple other organs." @default.
• W4210274744 created "2022-02-08" @default.
• W4210274744 creator A5007513209 @default.
• W4210274744 creator A5029341778 @default.
• W4210274744 creator A5030477066 @default.
• W4210274744 creator A5085052851 @default.
• W4210274744 date "2022-01-31" @default.
• W4210274744 modified "2023-10-17" @default.
• W4210274744 title "Timeline of Multi-Organ Plasma Extravasation After Bleomycin-Induced Acute Lung Injury" @default.
• W4210274744 cites W1879089985 @default.
• W4210274744 cites W1975484272 @default.
• W4210274744 cites W1982248376 @default.
• W4210274744 cites W1998457189 @default.
• W4210274744 cites W2064013566 @default.
• W4210274744 cites W2068436393 @default.
• W4210274744 cites W2068854215 @default.
• W4210274744 cites W2078711199 @default.
• W4210274744 cites W2092796495 @default.
• W4210274744 cites W2111791469 @default.
• W4210274744 cites W2116682551 @default.
• W4210274744 cites W2121190453 @default.
• W4210274744 cites W2127031103 @default.
• W4210274744 cites W2130618259 @default.
• W4210274744 cites W2133808995 @default.
• W4210274744 cites W2133897686 @default.
• W4210274744 cites W2171231179 @default.
• W4210274744 cites W2286228001 @default.
• W4210274744 cites W2317488575 @default.
• W4210274744 cites W2471686427 @default.
• W4210274744 cites W2496661162 @default.
• W4210274744 cites W2548267109 @default.
• W4210274744 cites W2620241325 @default.
• W4210274744 cites W2774093552 @default.
• W4210274744 cites W2848678871 @default.
• W4210274744 cites W2885197284 @default.
• W4210274744 cites W2887841170 @default.
• W4210274744 cites W2896048853 @default.
• W4210274744 cites W2925112189 @default.
• W4210274744 cites W2940519842 @default.
• W4210274744 cites W2944584167 @default.
• W4210274744 cites W2976456440 @default.
• W4210274744 cites W2978040015 @default.
• W4210274744 cites W2980687559 @default.
• W4210274744 cites W3009291243 @default.
• W4210274744 cites W3087370964 @default.
• W4210274744 cites W3145852856 @default.
• W4210274744 cites W4211250103 @default.
• W4210274744 cites W4244453408 @default.
• W4210274744 cites W4244510409 @default.
• W4210274744 cites W828016181 @default.
• W4210274744 doi "https://doi.org/10.3389/fphys.2022.777072" @default.
• W4210274744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35173628" @default.
• W4210274744 hasPublicationYear "2022" @default.
• W4210274744 type Work @default.
• W4210274744 citedByCount "8" @default.
• W4210274744 countsByYear W42102747442022 @default.
• W4210274744 countsByYear W42102747442023 @default.
• W4210274744 crossrefType "journal-article" @default.
• W4210274744 hasAuthorship W4210274744A5007513209 @default.
• W4210274744 hasAuthorship W4210274744A5029341778 @default.
• W4210274744 hasAuthorship W4210274744A5030477066 @default.
• W4210274744 hasAuthorship W4210274744A5085052851 @default.
• W4210274744 hasBestOaLocation W42102747441 @default.
• W4210274744 hasConcept C126322002 @default.
• W4210274744 hasConcept C142724271 @default.
• W4210274744 hasConcept C2776232574 @default.
• W4210274744 hasConcept C2776348555 @default.
• W4210274744 hasConcept C2776468924 @default.
• W4210274744 hasConcept C2776694085 @default.
• W4210274744 hasConcept C2777397205 @default.
• W4210274744 hasConcept C2777649898 @default.
• W4210274744 hasConcept C2777714996 @default.
• W4210274744 hasConcept C2779540182 @default.
• W4210274744 hasConcept C2780886150 @default.
• W4210274744 hasConcept C42219234 @default.
• W4210274744 hasConcept C71924100 @default.
• W4210274744 hasConceptScore W4210274744C126322002 @default.
• W4210274744 hasConceptScore W4210274744C142724271 @default.
• W4210274744 hasConceptScore W4210274744C2776232574 @default.
• W4210274744 hasConceptScore W4210274744C2776348555 @default.
• W4210274744 hasConceptScore W4210274744C2776468924 @default.
• W4210274744 hasConceptScore W4210274744C2776694085 @default.
• W4210274744 hasConceptScore W4210274744C2777397205 @default.
• W4210274744 hasConceptScore W4210274744C2777649898 @default.
• W4210274744 hasConceptScore W4210274744C2777714996 @default.
• W4210274744 hasConceptScore W4210274744C2779540182 @default.
• W4210274744 hasConceptScore W4210274744C2780886150 @default.
• W4210274744 hasConceptScore W4210274744C42219234 @default.
• W4210274744 hasConceptScore W4210274744C71924100 @default.
• W4210274744 hasFunder F4320332161 @default.
• W4210274744 hasLocation W42102747441 @default.
• W4210274744 hasLocation W42102747442 @default.
• W4210274744 hasLocation W42102747443 @default.
• W4210274744 hasOpenAccess W4210274744 @default.
• W4210274744 hasPrimaryLocation W42102747441 @default.
• W4210274744 hasRelatedWork W1999756701 @default.
• W4210274744 hasRelatedWork W2023597875 @default.
• W4210274744 hasRelatedWork W2070461592 @default.
• W4210274744 hasRelatedWork W2128273733 @default.
• W4210274744 hasRelatedWork W2143881383 @default.

• next