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- W4210276278 abstract "Early identification of patients with coronavirus disease-2019 (COVID-19) particularly those who develop critical illness is of great importance and aids in delivering proper treatment and optimizing the use of resources. This work aimed to develop a clinical score at hospital admission for COVID-19 diagnosis and predicting severe disease. This is a multicenter case-control study including 2793 PCR-confirmed consecutive COVID-19 patients and 251 patients without COVID-19 presented to 6 hospitals affiliated to the General Organization for Teaching Hospitals, Egypt (1st-May-2020 to 31st-July-2020). There was no difference among groups regarding age and gender distribution. Patients with COVID-19 had significantly higher white blood cell count, platelet count, ALT, AST, total serum bilirubin, serum creatinine, CRP, Ferritin, D-dimer, and fibrinogen and lower serum albumin and more prolonged INR. ALT, ferritin, D-dimer, and Fibrinogen were significantly higher and oxygen saturation was significantly lower, in patients with severe COVID-19. Multivariate regression analysis revealed Oxygen saturation, ferritin, D-dimer and CRP are the independent factors associated with severity. We developed a novel COVID model which enabled the correct diagnosis of COVID-19 at cutoff point (0.1) with an AUC=0.99, (P-value<0.0001), sensitivity 99%, and specificity 89%. At this point, COVID-19 severity could be diagnosed with AUC of 0.88, sensitivity 87%, specificity 71%." @default.
- W4210276278 created "2022-02-08" @default.
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- W4210276278 date "2021-12-30" @default.
- W4210276278 modified "2023-10-14" @default.
- W4210276278 title "Novel COVID Model to Help Early Diagnosis of COVID-19 and Prediction of Disease Severity: A Multicenter Study" @default.
- W4210276278 doi "https://doi.org/10.33425/2639-9458.1137" @default.
- W4210276278 hasPublicationYear "2021" @default.
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