Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210279509> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4210279509 endingPage "110391" @default.
- W4210279509 startingPage "110391" @default.
- W4210279509 abstract "Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to analyze whether an antiviral IFN-λ3 response is mounted after infection with bovine alphaherpesviruses (BoHV-1 and BoHV-5) in vitro, in neuronal-type cells, and in neural tissues from experimentally-infected calves. This study demonstrated that there is a strong IFN-λ3 response early after BoHV-1infection of undifferentiated neuroblastoma cells. During acute BoHV-1 and BoHV-5 infection of calves, low levels of IFN-λ3 expression were detected in the brain, which would favor virus spread within this tissue. Striking differences in the transcriptional levels of IFN-λ3 were observed in trigeminal ganglion, particularly in BoHV-1-acutely- and latently-infected calves. During reactivation, IFN-λ3 expression was down-regulated, which may be a requirement for virus replication and spread. Overall, different patterns of IFN-λ3 expression were detected during BoHV-1 and BoHV-5 infection, particularly during latency." @default.
- W4210279509 created "2022-02-08" @default.
- W4210279509 creator A5079347764 @default.
- W4210279509 creator A5080795220 @default.
- W4210279509 creator A5081132699 @default.
- W4210279509 creator A5082998599 @default.
- W4210279509 creator A5090407390 @default.
- W4210279509 date "2022-03-01" @default.
- W4210279509 modified "2023-10-06" @default.
- W4210279509 title "Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues" @default.
- W4210279509 cites W1561945694 @default.
- W4210279509 cites W1595341613 @default.
- W4210279509 cites W1841904820 @default.
- W4210279509 cites W1983873491 @default.
- W4210279509 cites W1987009823 @default.
- W4210279509 cites W1996432689 @default.
- W4210279509 cites W2002196074 @default.
- W4210279509 cites W2003907443 @default.
- W4210279509 cites W2012462671 @default.
- W4210279509 cites W2049334139 @default.
- W4210279509 cites W2059933691 @default.
- W4210279509 cites W2084237034 @default.
- W4210279509 cites W2086165702 @default.
- W4210279509 cites W2099249565 @default.
- W4210279509 cites W2100729748 @default.
- W4210279509 cites W2117228677 @default.
- W4210279509 cites W2133312651 @default.
- W4210279509 cites W2149308851 @default.
- W4210279509 cites W2150975910 @default.
- W4210279509 cites W2157043469 @default.
- W4210279509 cites W2157135427 @default.
- W4210279509 cites W2171315725 @default.
- W4210279509 cites W2346169485 @default.
- W4210279509 cites W2573069515 @default.
- W4210279509 cites W2757705091 @default.
- W4210279509 cites W2789834685 @default.
- W4210279509 cites W2942841445 @default.
- W4210279509 cites W2969750410 @default.
- W4210279509 cites W2994922699 @default.
- W4210279509 cites W3014121895 @default.
- W4210279509 cites W3022925573 @default.
- W4210279509 cites W3029030629 @default.
- W4210279509 cites W3117262306 @default.
- W4210279509 cites W4213222109 @default.
- W4210279509 cites W2022728910 @default.
- W4210279509 doi "https://doi.org/10.1016/j.vetimm.2022.110391" @default.
- W4210279509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35114600" @default.
- W4210279509 hasPublicationYear "2022" @default.
- W4210279509 type Work @default.
- W4210279509 citedByCount "5" @default.
- W4210279509 countsByYear W42102795092022 @default.
- W4210279509 countsByYear W42102795092023 @default.
- W4210279509 crossrefType "journal-article" @default.
- W4210279509 hasAuthorship W4210279509A5079347764 @default.
- W4210279509 hasAuthorship W4210279509A5080795220 @default.
- W4210279509 hasAuthorship W4210279509A5081132699 @default.
- W4210279509 hasAuthorship W4210279509A5082998599 @default.
- W4210279509 hasAuthorship W4210279509A5090407390 @default.
- W4210279509 hasConcept C136449434 @default.
- W4210279509 hasConcept C140704245 @default.
- W4210279509 hasConcept C159047783 @default.
- W4210279509 hasConcept C202751555 @default.
- W4210279509 hasConcept C203014093 @default.
- W4210279509 hasConcept C2522874641 @default.
- W4210279509 hasConcept C2776178377 @default.
- W4210279509 hasConcept C2779341262 @default.
- W4210279509 hasConcept C54355233 @default.
- W4210279509 hasConcept C86803240 @default.
- W4210279509 hasConcept C8891405 @default.
- W4210279509 hasConceptScore W4210279509C136449434 @default.
- W4210279509 hasConceptScore W4210279509C140704245 @default.
- W4210279509 hasConceptScore W4210279509C159047783 @default.
- W4210279509 hasConceptScore W4210279509C202751555 @default.
- W4210279509 hasConceptScore W4210279509C203014093 @default.
- W4210279509 hasConceptScore W4210279509C2522874641 @default.
- W4210279509 hasConceptScore W4210279509C2776178377 @default.
- W4210279509 hasConceptScore W4210279509C2779341262 @default.
- W4210279509 hasConceptScore W4210279509C54355233 @default.
- W4210279509 hasConceptScore W4210279509C86803240 @default.
- W4210279509 hasConceptScore W4210279509C8891405 @default.
- W4210279509 hasLocation W42102795091 @default.
- W4210279509 hasLocation W42102795092 @default.
- W4210279509 hasOpenAccess W4210279509 @default.
- W4210279509 hasPrimaryLocation W42102795091 @default.
- W4210279509 hasRelatedWork W1973676625 @default.
- W4210279509 hasRelatedWork W2010825098 @default.
- W4210279509 hasRelatedWork W2040999715 @default.
- W4210279509 hasRelatedWork W2066966091 @default.
- W4210279509 hasRelatedWork W2076610816 @default.
- W4210279509 hasRelatedWork W2103515427 @default.
- W4210279509 hasRelatedWork W2132748059 @default.
- W4210279509 hasRelatedWork W2148114753 @default.
- W4210279509 hasRelatedWork W2312143864 @default.
- W4210279509 hasRelatedWork W233723858 @default.
- W4210279509 hasVolume "245" @default.
- W4210279509 isParatext "false" @default.
- W4210279509 isRetracted "false" @default.
- W4210279509 workType "article" @default.