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• W4210282824 abstract "Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated morbidity and mortality worldwide. Short-course, oral, curative, direct-acting antiviral regimens have transformed treatment for HCV infection. Since the 2016 launch of the first global strategy towards elimination of viral hepatitis as a public health threat by 2030, the predominant focus of the global response has been on the treatment of adults, who bear the greatest burden of morbidity and mortality of HCV-related chronic liver disease. Compared with adults, there has been little attention paid to addressing the response to HCV in children and adolescents, in part because of the scarcity of data to inform specific paediatric management practices and policy. In this Series paper, we summarise knowledge on the epidemiology, natural history, and treatment of chronic HCV infection in adolescents and children, and we highlight key differences from infection acquired in adulthood. The estimated global prevalence and burden of HCV infection in children aged 1-19 years is 0·15%, corresponding to 3·5 million people (95% CI 3·1-3·9 million). HCV infection is usually asymptomatic during childhood, and cirrhosis and hepatocellular carcinoma are rare. Sofosbuvir with ledipasvir and sofosbuvir with ribavirin have received regulatory approval and guidelines recommend their use in adolescents aged 12 years and older with HCV infection. In April, 2019, glecaprevir with pibrentasvir also received regulatory approval for adolescents aged 12-17 years. Key actions to address the current policy gaps and achieve treatment scale-up that is comparable to that in adults include: establishment of a campaign on access to testing and treatment that is targeted at children and adolescents; fast-track evaluation of pan-genotypic regimens; and accelerated approval of paediatric formulations. Research gaps that need to be addressed include: age-specific prevalence studies of HCV viraemia in priority countries; further validation of non-invasive tests for staging of liver disease in children; and establishment of paediatric treatment registries and international consortia to promote collaborative research agendas." @default.
• W4210282824 created "2022-02-08" @default.
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• W4210282824 date "2019-06-01" @default.
• W4210282824 modified "2023-10-18" @default.
• W4210282824 title "Hepatitis C virus infection in children and adolescents" @default.
• W4210282824 cites W1766454808 @default.
• W4210282824 cites W1815703820 @default.
• W4210282824 cites W1953072908 @default.
• W4210282824 cites W1967229580 @default.
• W4210282824 cites W1968214408 @default.
• W4210282824 cites W1969030917 @default.
• W4210282824 cites W1969183922 @default.
• W4210282824 cites W1971011563 @default.
• W4210282824 cites W1977024529 @default.
• W4210282824 cites W1987648362 @default.
• W4210282824 cites W1988171027 @default.
• W4210282824 cites W1994947695 @default.
• W4210282824 cites W1997356314 @default.
• W4210282824 cites W2003977995 @default.
• W4210282824 cites W2008183247 @default.
• W4210282824 cites W2008995350 @default.
• W4210282824 cites W2010044342 @default.
• W4210282824 cites W2010400293 @default.
• W4210282824 cites W2021929421 @default.
• W4210282824 cites W2027476072 @default.
• W4210282824 cites W2031285393 @default.
• W4210282824 cites W2031414345 @default.
• W4210282824 cites W2040785319 @default.
• W4210282824 cites W2049025324 @default.
• W4210282824 cites W2049029155 @default.
• W4210282824 cites W2049872768 @default.
• W4210282824 cites W2054850951 @default.
• W4210282824 cites W2057407106 @default.
• W4210282824 cites W2060363482 @default.
• W4210282824 cites W2060391643 @default.
• W4210282824 cites W2064696362 @default.
• W4210282824 cites W2065631609 @default.
• W4210282824 cites W2068207726 @default.
• W4210282824 cites W2092471934 @default.
• W4210282824 cites W2094856729 @default.
• W4210282824 cites W2095353496 @default.
• W4210282824 cites W2098082628 @default.
• W4210282824 cites W2098141210 @default.
• W4210282824 cites W2103370354 @default.
• W4210282824 cites W2106110144 @default.
• W4210282824 cites W2109569959 @default.
• W4210282824 cites W2112873828 @default.
• W4210282824 cites W2113755739 @default.
• W4210282824 cites W2119352414 @default.
• W4210282824 cites W2135836213 @default.
• W4210282824 cites W2136165756 @default.
• W4210282824 cites W2137052325 @default.
• W4210282824 cites W2137401503 @default.
• W4210282824 cites W2142866037 @default.
• W4210282824 cites W2143681435 @default.
• W4210282824 cites W2151716437 @default.
• W4210282824 cites W2154527433 @default.
• W4210282824 cites W2157776721 @default.
• W4210282824 cites W2158566694 @default.
• W4210282824 cites W2159055202 @default.
• W4210282824 cites W2166272676 @default.
• W4210282824 cites W2178343529 @default.
• W4210282824 cites W2185218296 @default.
• W4210282824 cites W2287453238 @default.
• W4210282824 cites W2319627770 @default.
• W4210282824 cites W2323539876 @default.
• W4210282824 cites W2327525734 @default.
• W4210282824 cites W2332785053 @default.
• W4210282824 cites W2342618707 @default.
• W4210282824 cites W2346049717 @default.
• W4210282824 cites W2483819174 @default.
• W4210282824 cites W2501804917 @default.
• W4210282824 cites W2519730243 @default.
• W4210282824 cites W2523165866 @default.
• W4210282824 cites W2529570932 @default.
• W4210282824 cites W255235625 @default.
• W4210282824 cites W2562725767 @default.
• W4210282824 cites W2581561133 @default.
• W4210282824 cites W2613425069 @default.
• W4210282824 cites W2614067092 @default.
• W4210282824 cites W2618208808 @default.
• W4210282824 cites W2620318023 @default.
• W4210282824 cites W2742837303 @default.

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