FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210285405> ?p ?o ?g. }

• W4210285405 abstract "ABSTRACT Therapeutics that target the envelope glycoproteins (Envs) of human immunodeficiency virus type 1 (HIV-1) effectively reduce virus levels in patients. However, due to mutations, new Env variants are frequently generated, which may be resistant to the treatments. The appearance of such sequence variance at any Env position is seemingly random. A better understanding of the spatiotemporal patterns of variance across Env may lead to the development of new therapeutic strategies. We hypothesized that, at any time point in a patient, positions with sequence variance are clustered on the three-dimensional structure of Env. To test this hypothesis, we examined whether variance at any Env position can be predicted by the variance measured at adjacent positions. Sequences from 300 HIV-infected patients were applied to a new algorithm we developed. The k-best classifiers (KBC) method is a dynamic ensemble selection technique that identifies the best classifier(s) within the neighborhood of a new observation. It applies bootstrap resampling to generate out-of-bag samples that are used with the resampled set to evaluate each classifier. For many positions of Env, primarily in the CD4-binding site, KBC accurately predicted variance based on the variance at their adjacent positions. KBC improved performance compared to the initial learners, static ensemble, and other baseline models. KBC also outperformed other algorithms for predicting variance at multi-position footprints of therapeutics on Env. These understandings can be applied to refine models that predict future changes in HIV-1 Env. More generally, we propose KBC as a new high-performance dynamic ensemble selection technique." @default.
• W4210285405 created "2022-02-08" @default.
• W4210285405 creator A5018901631 @default.
• W4210285405 creator A5028485114 @default.
• W4210285405 creator A5049805665 @default.
• W4210285405 creator A5059362364 @default.
• W4210285405 creator A5072517008 @default.
• W4210285405 creator A5075640512 @default.
• W4210285405 date "2022-02-02" @default.
• W4210285405 modified "2023-09-25" @default.
• W4210285405 title "A New Classification Method Based on Dynamic Ensemble Selection and its Application to Predict Variance Patterns in HIV-1 Env" @default.
• W4210285405 cites W1582721835 @default.
• W4210285405 cites W1906991280 @default.
• W4210285405 cites W1924338894 @default.
• W4210285405 cites W1984879178 @default.
• W4210285405 cites W1991257948 @default.
• W4210285405 cites W1997677784 @default.
• W4210285405 cites W2004294122 @default.
• W4210285405 cites W2014764918 @default.
• W4210285405 cites W2026568527 @default.
• W4210285405 cites W2038110764 @default.
• W4210285405 cites W2051445869 @default.
• W4210285405 cites W2055448283 @default.
• W4210285405 cites W2063706234 @default.
• W4210285405 cites W2068757386 @default.
• W4210285405 cites W2071829412 @default.
• W4210285405 cites W2072854137 @default.
• W4210285405 cites W2090126383 @default.
• W4210285405 cites W2098154993 @default.
• W4210285405 cites W2104318155 @default.
• W4210285405 cites W2106197195 @default.
• W4210285405 cites W2113236498 @default.
• W4210285405 cites W2121558572 @default.
• W4210285405 cites W2121914783 @default.
• W4210285405 cites W2126515754 @default.
• W4210285405 cites W2145940431 @default.
• W4210285405 cites W2146906064 @default.
• W4210285405 cites W2147564534 @default.
• W4210285405 cites W2148245437 @default.
• W4210285405 cites W2149204499 @default.
• W4210285405 cites W2153163225 @default.
• W4210285405 cites W2170614926 @default.
• W4210285405 cites W2174468353 @default.
• W4210285405 cites W2198318089 @default.
• W4210285405 cites W2260088076 @default.
• W4210285405 cites W2332658587 @default.
• W4210285405 cites W2340411134 @default.
• W4210285405 cites W2538534228 @default.
• W4210285405 cites W2548549162 @default.
• W4210285405 cites W2572760626 @default.
• W4210285405 cites W2583112160 @default.
• W4210285405 cites W2604977567 @default.
• W4210285405 cites W2750272252 @default.
• W4210285405 cites W2783450464 @default.
• W4210285405 cites W2783515291 @default.
• W4210285405 cites W2790276942 @default.
• W4210285405 cites W2794768685 @default.
• W4210285405 cites W2808034668 @default.
• W4210285405 cites W2888074758 @default.
• W4210285405 cites W2899687428 @default.
• W4210285405 cites W2902415114 @default.
• W4210285405 cites W2907590256 @default.
• W4210285405 cites W2909100863 @default.
• W4210285405 cites W2955636540 @default.
• W4210285405 cites W2969257846 @default.
• W4210285405 cites W2980139506 @default.
• W4210285405 cites W2981372844 @default.
• W4210285405 cites W3007425615 @default.
• W4210285405 cites W3008033034 @default.
• W4210285405 cites W3033559620 @default.
• W4210285405 cites W3033659911 @default.
• W4210285405 cites W3047350970 @default.
• W4210285405 cites W3047351579 @default.
• W4210285405 cites W3097331958 @default.
• W4210285405 doi "https://doi.org/10.1101/2022.01.31.478521" @default.
• W4210285405 hasPublicationYear "2022" @default.
• W4210285405 type Work @default.
• W4210285405 citedByCount "0" @default.
• W4210285405 crossrefType "posted-content" @default.
• W4210285405 hasAuthorship W4210285405A5018901631 @default.
• W4210285405 hasAuthorship W4210285405A5028485114 @default.
• W4210285405 hasAuthorship W4210285405A5049805665 @default.
• W4210285405 hasAuthorship W4210285405A5059362364 @default.
• W4210285405 hasAuthorship W4210285405A5072517008 @default.
• W4210285405 hasAuthorship W4210285405A5075640512 @default.
• W4210285405 hasBestOaLocation W42102854051 @default.
• W4210285405 hasConcept C10138342 @default.
• W4210285405 hasConcept C11413529 @default.
• W4210285405 hasConcept C119857082 @default.
• W4210285405 hasConcept C121955636 @default.
• W4210285405 hasConcept C144133560 @default.
• W4210285405 hasConcept C150921843 @default.
• W4210285405 hasConcept C153180895 @default.
• W4210285405 hasConcept C154945302 @default.
• W4210285405 hasConcept C159047783 @default.
• W4210285405 hasConcept C162324750 @default.
• W4210285405 hasConcept C196083921 @default.
• W4210285405 hasConcept C198082294 @default.
• W4210285405 hasConcept C3013748606 @default.
• W4210285405 hasConcept C41008148 @default.

• next