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- W4210291289 abstract "Opioid analgesics continue to play a major role in the treatment of moderate-to-severe pain. However, the need for the development of newer opioid agonists for analgesia has been limited for a variety of reasons including the plethora of agents currently available, the long term clinical experience with opioid analgesics and the multitude of strategies aimed at reducing their use due to the ongoing opioid epidemic. A comprehensive literature search using PubMed was performed to identify any reports of new opioid related adverse reactions, drug–drug interactions or pharmacogenetic considerations in humans between January 2019 and December 2019. New adverse effects have been reported with potent synthetic opioid agonist, such as U-47700 and Krokodil, which are known substances of misuse (Fels et al., 2019; Zidkova et al., 2018; van Kempen et al., 2019; Hakobyan et al., 2019). Hypoglycemia from opioid analgesics now include partial agonists such as nalbuphine. This supports opioid induced hypoglycemia may be a class affect. Recent publications indicate a significant increase in development and use of oral opioid antagonist for the treatment of opioid induced constipation (OIC). Common adverse effects of these agents as a class may include nausea, vomiting, diarrhea and sweating (Ishii et al., 2020; Saito et al., 2018)." @default.
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- W4210291289 date "2020-01-01" @default.
- W4210291289 modified "2023-10-17" @default.
- W4210291289 title "Opioid analgesics and narcotic antagonists" @default.
- W4210291289 doi "https://doi.org/10.1016/bs.seda.2020.09.002" @default.
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