FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210293313> ?p ?o ?g. }

• W4210293313 endingPage "596" @default.
• W4210293313 startingPage "582" @default.
• W4210293313 abstract "The avidity of TCRs for peptide-major histocompatibility complexes (pMHCs) is a governing factor in how T cells respond to antigen. TCR avidity is generally linked to T-cell functionality and there is growing evidence for distinct roles of low and high avidity T cells in different phases of immune responses. While physiological immune responses and many therapeutic T-cell products targeting infections or cancers consist of polyclonal T-cell populations with a wide range of individual avidities, the role of T-cell avidity is usually investigated only in monoclonal experimental settings. In this report, we induced polyclonal T-cell responses with a wide range of avidities toward a model epitope by altered peptide ligands, and benchmarked global avidity of physiological polyclonal populations by investigation of TCR-pMHC koff -rates. We then investigated how varying sizes and avidities of monoclonal subpopulations translate into global koff -rates. Global koff -rates integrate subclonal avidities in a predictably weighted manner and robustly correlate with the functionality of murine polyclonal T-cell populations in vitro and in vivo. Surveying the full avidity spectrum is essential to accurately assess polyclonal immune responses and inform the design of polyclonal T-cell therapeutics." @default.
• W4210293313 created "2022-02-08" @default.
• W4210293313 creator A5001597492 @default.
• W4210293313 creator A5002329046 @default.
• W4210293313 creator A5011501010 @default.
• W4210293313 creator A5013146486 @default.
• W4210293313 creator A5018806211 @default.
• W4210293313 creator A5020533547 @default.
• W4210293313 creator A5032669745 @default.
• W4210293313 creator A5060842430 @default.
• W4210293313 creator A5062895290 @default.
• W4210293313 creator A5078793182 @default.
• W4210293313 date "2022-02-13" @default.
• W4210293313 modified "2023-09-27" @default.
• W4210293313 title "Global <i>k</i>_off‐rates of polyclonal T‐cell populations merge subclonal avidities and predict functionality" @default.
• W4210293313 cites W1532828658 @default.
• W4210293313 cites W1558649589 @default.
• W4210293313 cites W1589097025 @default.
• W4210293313 cites W1964115378 @default.
• W4210293313 cites W1964823826 @default.
• W4210293313 cites W1965247885 @default.
• W4210293313 cites W1982288970 @default.
• W4210293313 cites W1989199118 @default.
• W4210293313 cites W1996483176 @default.
• W4210293313 cites W1998511867 @default.
• W4210293313 cites W2004772469 @default.
• W4210293313 cites W2020929096 @default.
• W4210293313 cites W2026875548 @default.
• W4210293313 cites W2032166347 @default.
• W4210293313 cites W2056225975 @default.
• W4210293313 cites W2058634008 @default.
• W4210293313 cites W2058645356 @default.
• W4210293313 cites W2065635440 @default.
• W4210293313 cites W2074545819 @default.
• W4210293313 cites W2078494443 @default.
• W4210293313 cites W2091218020 @default.
• W4210293313 cites W2117535233 @default.
• W4210293313 cites W2125066454 @default.
• W4210293313 cites W2127745456 @default.
• W4210293313 cites W2137021531 @default.
• W4210293313 cites W2140574666 @default.
• W4210293313 cites W2166213184 @default.
• W4210293313 cites W2518456710 @default.
• W4210293313 cites W2563681779 @default.
• W4210293313 cites W2573546687 @default.
• W4210293313 cites W2737422738 @default.
• W4210293313 cites W2788334670 @default.
• W4210293313 cites W2810686477 @default.
• W4210293313 cites W2912739653 @default.
• W4210293313 cites W2973409297 @default.
• W4210293313 cites W3010735835 @default.
• W4210293313 cites W4200079077 @default.
• W4210293313 cites W4231014363 @default.
• W4210293313 cites W951670699 @default.
• W4210293313 doi "https://doi.org/10.1002/eji.202149597" @default.
• W4210293313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35099805" @default.
• W4210293313 hasPublicationYear "2022" @default.
• W4210293313 type Work @default.
• W4210293313 citedByCount "0" @default.
• W4210293313 crossrefType "journal-article" @default.
• W4210293313 hasAuthorship W4210293313A5001597492 @default.
• W4210293313 hasAuthorship W4210293313A5002329046 @default.
• W4210293313 hasAuthorship W4210293313A5011501010 @default.
• W4210293313 hasAuthorship W4210293313A5013146486 @default.
• W4210293313 hasAuthorship W4210293313A5018806211 @default.
• W4210293313 hasAuthorship W4210293313A5020533547 @default.
• W4210293313 hasAuthorship W4210293313A5032669745 @default.
• W4210293313 hasAuthorship W4210293313A5060842430 @default.
• W4210293313 hasAuthorship W4210293313A5062895290 @default.
• W4210293313 hasAuthorship W4210293313A5078793182 @default.
• W4210293313 hasBestOaLocation W42102933131 @default.
• W4210293313 hasConcept C147483822 @default.
• W4210293313 hasConcept C179223381 @default.
• W4210293313 hasConcept C19317047 @default.
• W4210293313 hasConcept C195616568 @default.
• W4210293313 hasConcept C203014093 @default.
• W4210293313 hasConcept C2776090121 @default.
• W4210293313 hasConcept C86803240 @default.
• W4210293313 hasConcept C8891405 @default.
• W4210293313 hasConcept C956191 @default.
• W4210293313 hasConceptScore W4210293313C147483822 @default.
• W4210293313 hasConceptScore W4210293313C179223381 @default.
• W4210293313 hasConceptScore W4210293313C19317047 @default.
• W4210293313 hasConceptScore W4210293313C195616568 @default.
• W4210293313 hasConceptScore W4210293313C203014093 @default.
• W4210293313 hasConceptScore W4210293313C2776090121 @default.
• W4210293313 hasConceptScore W4210293313C86803240 @default.
• W4210293313 hasConceptScore W4210293313C8891405 @default.
• W4210293313 hasConceptScore W4210293313C956191 @default.
• W4210293313 hasIssue "4" @default.
• W4210293313 hasLocation W42102933131 @default.
• W4210293313 hasLocation W42102933132 @default.
• W4210293313 hasLocation W42102933133 @default.
• W4210293313 hasLocation W42102933134 @default.
• W4210293313 hasOpenAccess W4210293313 @default.
• W4210293313 hasPrimaryLocation W42102933131 @default.
• W4210293313 hasRelatedWork W1977052700 @default.
• W4210293313 hasRelatedWork W1980985575 @default.

• next