FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210298174> ?p ?o ?g. }

• W4210298174 abstract "<sec> <title>BACKGROUND</title> Experimental and epidemiologic studies have shown that circadian clocks’ disruption can play an important role in the development of cancer and metabolic diseases. The cellular clocks outside the brain are effectively coordinated by the body temperature rhythm. We hypothesized that concurrent measurements of body temperature and rest-activity rhythms would assess circadian clocks coordination in individual patients, thus enabling the integration of biological rhythms into precision medicine. </sec> <sec> <title>OBJECTIVE</title> The objective was to evaluate the circadian clocks’ coordination in healthy subjects and patients through simultaneous measurements of rest-activity and body temperature rhythms. </sec> <sec> <title>METHODS</title> Noninvasive real-time measurements of rest-activity and chest temperature rhythms were recorded during the subject’s daily life, using a dedicated new mobile electronic health platform (PiCADo). It involved a chest sensor that jointly measured accelerations, 3D orientation, and skin surface temperature every 1-5 min and relayed them out to a mobile gateway via Bluetooth Low Energy. The gateway tele-transmitted all stored data to a server via General Packet Radio Service every 24 hours. The technical capabilities of PiCADo were validated in 55 healthy subjects and 12 cancer patients, whose rhythms were e-monitored during their daily routine for 3-30 days. Spectral analyses enabled to compute rhythm parameters values, with their 90% confidence limits, and their dynamics in each subject. </sec> <sec> <title>RESULTS</title> All the individuals displayed a dominant circadian rhythm in activity with maxima occurring from 12:09 to 20:25. This was not the case for the dominant temperature period, which clustered around 24 hours for 51 out of 67 subjects (76%), and around 12 hours for 13 others (19%). Statistically significant sex- and age-related differences in circadian coordination were identified in the noncancerous subjects, based upon the range of variations in temperature rhythm amplitudes, maxima (acrophases), and phase relations with rest-activity. The circadian acrophase of chest temperature was located at night for the majority of people, but it occurred at daytime for 26% (14/55) of the noncancerous people and 33% (4/12) of the cancer patients, thus supporting important intersubject differences in circadian coordination. Sex, age, and cancer significantly impacted the circadian coordination of both rhythms, based on their phase relationships. </sec> <sec> <title>CONCLUSIONS</title> Complementing rest-activity with chest temperature circadian e-monitoring revealed striking intersubject differences regarding human circadian clocks’ coordination and timing during daily routine. To further delineate the clinical importance of such finding, the PiCADo platform is currently applied for both the assessment of health effects resulting from atypical work schedules and the identification of the key determinants of circadian disruption in cancer patients. </sec>" @default.
• W4210298174 created "2022-02-08" @default.
• W4210298174 creator A5000057889 @default.
• W4210298174 creator A5000726989 @default.
• W4210298174 creator A5000959718 @default.
• W4210298174 creator A5009760448 @default.
• W4210298174 creator A5032033686 @default.
• W4210298174 creator A5037937397 @default.
• W4210298174 creator A5038190117 @default.
• W4210298174 creator A5068491867 @default.
• W4210298174 creator A5071841070 @default.
• W4210298174 creator A5073384030 @default.
• W4210298174 creator A5077164990 @default.
• W4210298174 creator A5078259466 @default.
• W4210298174 date "2018-01-05" @default.
• W4210298174 modified "2023-10-18" @default.
• W4210298174 title "Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study (Preprint)" @default.
• W4210298174 cites W1545480108 @default.
• W4210298174 cites W1972576332 @default.
• W4210298174 cites W1984912966 @default.
• W4210298174 cites W2022593462 @default.
• W4210298174 cites W2059748915 @default.
• W4210298174 cites W2064889359 @default.
• W4210298174 cites W2070375592 @default.
• W4210298174 cites W2085483223 @default.
• W4210298174 cites W2095921750 @default.
• W4210298174 cites W2104264189 @default.
• W4210298174 cites W2112211373 @default.
• W4210298174 cites W2266777191 @default.
• W4210298174 cites W2332542558 @default.
• W4210298174 cites W2551087603 @default.
• W4210298174 cites W2555865797 @default.
• W4210298174 cites W2620925856 @default.
• W4210298174 cites W2654846770 @default.
• W4210298174 cites W4211057115 @default.
• W4210298174 doi "https://doi.org/10.2196/preprints.9779" @default.
• W4210298174 hasPublicationYear "2018" @default.
• W4210298174 type Work @default.
• W4210298174 citedByCount "0" @default.
• W4210298174 crossrefType "posted-content" @default.
• W4210298174 hasAuthorship W4210298174A5000057889 @default.
• W4210298174 hasAuthorship W4210298174A5000726989 @default.
• W4210298174 hasAuthorship W4210298174A5000959718 @default.
• W4210298174 hasAuthorship W4210298174A5009760448 @default.
• W4210298174 hasAuthorship W4210298174A5032033686 @default.
• W4210298174 hasAuthorship W4210298174A5037937397 @default.
• W4210298174 hasAuthorship W4210298174A5038190117 @default.
• W4210298174 hasAuthorship W4210298174A5068491867 @default.
• W4210298174 hasAuthorship W4210298174A5071841070 @default.
• W4210298174 hasAuthorship W4210298174A5073384030 @default.
• W4210298174 hasAuthorship W4210298174A5077164990 @default.
• W4210298174 hasAuthorship W4210298174A5078259466 @default.
• W4210298174 hasBestOaLocation W42102981742 @default.
• W4210298174 hasConcept C121446783 @default.
• W4210298174 hasConcept C126322002 @default.
• W4210298174 hasConcept C135343436 @default.
• W4210298174 hasConcept C15744967 @default.
• W4210298174 hasConcept C38606739 @default.
• W4210298174 hasConcept C41008148 @default.
• W4210298174 hasConcept C71924100 @default.
• W4210298174 hasConceptScore W4210298174C121446783 @default.
• W4210298174 hasConceptScore W4210298174C126322002 @default.
• W4210298174 hasConceptScore W4210298174C135343436 @default.
• W4210298174 hasConceptScore W4210298174C15744967 @default.
• W4210298174 hasConceptScore W4210298174C38606739 @default.
• W4210298174 hasConceptScore W4210298174C41008148 @default.
• W4210298174 hasConceptScore W4210298174C71924100 @default.
• W4210298174 hasLocation W42102981741 @default.
• W4210298174 hasLocation W42102981742 @default.
• W4210298174 hasOpenAccess W4210298174 @default.
• W4210298174 hasPrimaryLocation W42102981741 @default.
• W4210298174 hasRelatedWork W2032514270 @default.
• W4210298174 hasRelatedWork W2083248444 @default.
• W4210298174 hasRelatedWork W2088598710 @default.
• W4210298174 hasRelatedWork W2146600670 @default.
• W4210298174 hasRelatedWork W2147418085 @default.
• W4210298174 hasRelatedWork W2147479273 @default.
• W4210298174 hasRelatedWork W2748952813 @default.
• W4210298174 hasRelatedWork W2899084033 @default.
• W4210298174 hasRelatedWork W3031147190 @default.
• W4210298174 hasRelatedWork W4281720369 @default.
• W4210298174 isParatext "false" @default.
• W4210298174 isRetracted "false" @default.
• W4210298174 workType "article" @default.