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- W4210300432 abstract "This chapter provides an overview of several unique properties of natural autoantibodies (NAA) along with potential significance that supports a role for NAA in biologic regulation. NAA are self-reacting serum antibodies that do not require antigenic stimuli for their production and express polyreactivity and fine specificities. The majority of NAA are capable of reacting with three or more self or nonself antigens. A small group of NAA is considered monoreactive with specificity for a given antigen. Natural immunoglobulin type G (IgG) antikeratin antibodies induce the elimination of keratin after keratinocyte death, which results in local accumulation of high concentrations of keratin. The subsequent binding of IgG facilitates phagocytosis of the resultant immune complexes. The possible pathogenic properties of NAA are best exemplified by animal models, which demonstrate that end-organ damage can result from immunization with NAA. NAA play an active role in the preservation and perpetuation of the normal balanced immune response in several ways by virtue of their unique biochemical and physical properties." @default.
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- W4210300432 date "1996-01-01" @default.
- W4210300432 modified "2023-09-27" @default.
- W4210300432 title "Natural Autoantibodies" @default.
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- W4210300432 doi "https://doi.org/10.1016/b978-044482383-0/50082-0" @default.
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