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• W4210304562 abstract "Hydrogels can maintain a high local drug concentration during treatments and may be useful to local targeting diseased areas. We propose a pH sensitive hydrogel consisting of poly-vinylpyrrolidone (PVP) and chitosan as a new treatment method for KRAS mutant lung cancer. Addition of dopamine improved the drug loading and release effects of this hydrogel. We demonstrate that Tasquinimod-loading of this dopamine-modified pH sensitive hydrogel is more effective than Tasquinimod alone for inhibiting the proliferation of KRAS mutant lung cancer cells. Combination of conventional drugs with hydrogels may thus provide a new treatment modality for lung cancer." @default.
• W4210304562 created "2022-02-08" @default.
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• W4210304562 date "2022-01-01" @default.
• W4210304562 modified "2023-10-18" @default.
• W4210304562 title "A Tasquinomod-loaded dopamine-modified pH sensitive hydrogel is effective at inhibiting the proliferation of KRAS mutant lung cancer cells" @default.
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• W4210304562 doi "https://doi.org/10.1177/22808000211073729" @default.
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• W4210304562 hasPublicationYear "2022" @default.
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