FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210309968> ?p ?o ?g. }

• W4210309968 endingPage "2313" @default.
• W4210309968 startingPage "2295" @default.
• W4210309968 abstract "The present study aims to assess a proposed treatment approach or therapy for periodontitis by using the in-silico technique. The proposed treatment strategy offers a singular vehicular system consisting of minocycline (antibiotic), celecoxib (selective COX-II inhibitor), doxycycline hyclate (matrix metalloproteinase inhibitor), and hydroxyapatite (osteogenic agent).Molecular docking studies of drugs were performed using Maestro version 9.4 software Schrödinger, and 3-Dimensional Crystallographic X-ray protein structures of targeted proteins were downloaded from RCSB protein data bank in .pdb file format. These agents were docked, and their affinities towards the receptors/protein/enzyme were calculated. Furthermore, their affinities were compared with the standard drug.The study suggests that minocycline and metronidazole possess equal affinity towards the RGPB and Inlj protein of P.gingivalis. Celecoxib, a well-known inhibitor of the COX-II enzyme, showed very high affinity. Selective inhibitor of MMP-8 possessed higher affinity than doxycycline, whereas CMT-3 showed equal affinity as doxycycline for MMP-13. Similarly, hydroxyapatite and simvastatin also showed a comparatively similar affinity for osteopontin receptor.Based upon molecular docking results, it can be concluded that the proposed treatment strategy would be a suitable approach for periodontitis and all the selected therapeutic agents have potential similar to the standard drugs, thereby constituting a reliable system for periodontitis." @default.
• W4210309968 created "2022-02-08" @default.
• W4210309968 creator A5006522980 @default.
• W4210309968 creator A5008070418 @default.
• W4210309968 creator A5009125191 @default.
• W4210309968 creator A5009796917 @default.
• W4210309968 creator A5021626690 @default.
• W4210309968 creator A5061023750 @default.
• W4210309968 creator A5066989709 @default.
• W4210309968 creator A5076373879 @default.
• W4210309968 date "2022-09-21" @default.
• W4210309968 modified "2023-09-24" @default.
• W4210309968 title "<i>In-silico</i> Validation of the Proposed Treatment Strategy of Periodontitis" @default.
• W4210309968 cites W1497141930 @default.
• W4210309968 cites W1991639866 @default.
• W4210309968 cites W1991862324 @default.
• W4210309968 cites W1992069165 @default.
• W4210309968 cites W2024394228 @default.
• W4210309968 cites W2035735673 @default.
• W4210309968 cites W2053692387 @default.
• W4210309968 cites W2109465854 @default.
• W4210309968 cites W2122711376 @default.
• W4210309968 cites W2325753259 @default.
• W4210309968 cites W2567465335 @default.
• W4210309968 cites W2591462746 @default.
• W4210309968 cites W2729576061 @default.
• W4210309968 cites W2802273451 @default.
• W4210309968 cites W2808067098 @default.
• W4210309968 cites W2918739365 @default.
• W4210309968 cites W2971698920 @default.
• W4210309968 cites W2995001173 @default.
• W4210309968 cites W3008859396 @default.
• W4210309968 cites W3068257868 @default.
• W4210309968 doi "https://doi.org/10.2174/1386207325666220126102235" @default.
• W4210309968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35081885" @default.
• W4210309968 hasPublicationYear "2022" @default.
• W4210309968 type Work @default.
• W4210309968 citedByCount "0" @default.
• W4210309968 crossrefType "journal-article" @default.
• W4210309968 hasAuthorship W4210309968A5006522980 @default.
• W4210309968 hasAuthorship W4210309968A5008070418 @default.
• W4210309968 hasAuthorship W4210309968A5009125191 @default.
• W4210309968 hasAuthorship W4210309968A5009796917 @default.
• W4210309968 hasAuthorship W4210309968A5021626690 @default.
• W4210309968 hasAuthorship W4210309968A5061023750 @default.
• W4210309968 hasAuthorship W4210309968A5066989709 @default.
• W4210309968 hasAuthorship W4210309968A5076373879 @default.
• W4210309968 hasConcept C104317684 @default.
• W4210309968 hasConcept C119145174 @default.
• W4210309968 hasConcept C126322002 @default.
• W4210309968 hasConcept C159110408 @default.
• W4210309968 hasConcept C185592680 @default.
• W4210309968 hasConcept C2775905019 @default.
• W4210309968 hasConcept C2776467144 @default.
• W4210309968 hasConcept C2777396551 @default.
• W4210309968 hasConcept C2778275353 @default.
• W4210309968 hasConcept C2780385504 @default.
• W4210309968 hasConcept C41685203 @default.
• W4210309968 hasConcept C47701112 @default.
• W4210309968 hasConcept C501593827 @default.
• W4210309968 hasConcept C55493867 @default.
• W4210309968 hasConcept C65556437 @default.
• W4210309968 hasConcept C70721500 @default.
• W4210309968 hasConcept C71924100 @default.
• W4210309968 hasConcept C86803240 @default.
• W4210309968 hasConcept C98274493 @default.
• W4210309968 hasConceptScore W4210309968C104317684 @default.
• W4210309968 hasConceptScore W4210309968C119145174 @default.
• W4210309968 hasConceptScore W4210309968C126322002 @default.
• W4210309968 hasConceptScore W4210309968C159110408 @default.
• W4210309968 hasConceptScore W4210309968C185592680 @default.
• W4210309968 hasConceptScore W4210309968C2775905019 @default.
• W4210309968 hasConceptScore W4210309968C2776467144 @default.
• W4210309968 hasConceptScore W4210309968C2777396551 @default.
• W4210309968 hasConceptScore W4210309968C2778275353 @default.
• W4210309968 hasConceptScore W4210309968C2780385504 @default.
• W4210309968 hasConceptScore W4210309968C41685203 @default.
• W4210309968 hasConceptScore W4210309968C47701112 @default.
• W4210309968 hasConceptScore W4210309968C501593827 @default.
• W4210309968 hasConceptScore W4210309968C55493867 @default.
• W4210309968 hasConceptScore W4210309968C65556437 @default.
• W4210309968 hasConceptScore W4210309968C70721500 @default.
• W4210309968 hasConceptScore W4210309968C71924100 @default.
• W4210309968 hasConceptScore W4210309968C86803240 @default.
• W4210309968 hasConceptScore W4210309968C98274493 @default.
• W4210309968 hasFunder F4320320721 @default.
• W4210309968 hasFunder F4320324433 @default.
• W4210309968 hasIssue "13" @default.
• W4210309968 hasLocation W42103099681 @default.
• W4210309968 hasLocation W42103099682 @default.
• W4210309968 hasOpenAccess W4210309968 @default.
• W4210309968 hasPrimaryLocation W42103099681 @default.
• W4210309968 hasRelatedWork W2028398649 @default.
• W4210309968 hasRelatedWork W2888207074 @default.
• W4210309968 hasRelatedWork W3033333373 @default.
• W4210309968 hasRelatedWork W3043954734 @default.
• W4210309968 hasRelatedWork W3176714861 @default.
• W4210309968 hasRelatedWork W3207537951 @default.

• next