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- W4210311920 abstract "We previously reported a tetrahelical monomolecular architecture of DNA, tmDNA, which employs G-quartets and an all-parallel GGGTGGGTGGGTGGG (G3T) quadruplex as the repeating unit. Based on thermodynamic and kinetic studies, we proposed that covalently joined (G3T) n units formed an uninterrupted programmable homopolymer; however, structural evidence for the tmDNA architecture was lacking. Here, we used NMR spectroscopy of wild-type and single-inosine-substituted constructs to characterize both monomolecular (G3T)2 and bimolecular quadruplex-Mg-coupled versions of tmDNA. The NMR results support an architecture consisting of uninterrupted stacked G-tetrads in both the monomolecular constructs and bimolecular assemblies. Taken together, these data support the formation of a stable programmable homopolymeric tmDNA architecture, which may have been a precursor to the modern-day Watson-Crick DNA duplex." @default.
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- W4210311920 date "2022-01-26" @default.
- W4210311920 modified "2023-09-26" @default.
- W4210311920 title "Structure of Tetrahelical DNA Homopolymers Supports Quadruplex World Hypothesis" @default.
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- W4210311920 doi "https://doi.org/10.1021/acsomega.1c06026" @default.
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