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- W4210314573 abstract "Due to the broad spectrum of Sars-Cov-2 infection´s clinical manifestations, some biomarkers have been investigated to predict its severity and evolution. Exhaled nitric oxide,(FeNO), a T2 inflammatory marker, has also been study in respiratory infections (viral, bacterial and fungal) with or without pneumonia . The aim of this study was to evaluate the role of FeNO as a marker of severity in SARS-CoV-2 disease Subjects with SARS-CoV-2 infection, attended between January to June 2021 were included in the study. A control group with suspected respiratory infection (SARS-CoV-2 negative) was also included. FeNO levels were measured in duplicate: the first measurement during acute viral symptoms and the second one at least 10 days later (infection recovery). Data collected included demographic, clinical and disease characteristics, presence of pneumonia and treatment. Eighty-two patients were included and divided into 3 groups depending on WHO SARS-CoV-2 severity classification: 25 patients with mild infection, 26 with moderate pneumonia and 31 with severe pneumonia. Eighteen patients conformed to the control group Mean FeNO (ppb) levels for SARS-CoV-2-positive patients were low at baseline with no significant variation during recovery: 12.9(12.2) vs 20.6(22.9), p=0.13 for mild infection, 12.9(12.8) vs 21.3(24.9), p=0.2 for moderate pneumonia and 12.9(12,8) vs 21.3(24.9) p=0.4 for severe pneumonia. There was no significant difference in FeNO value according to disease´ severity (p>0.05). Patients treated wirh systemic steroids had a significant lower levels at follow-up. FeNO levels are decreased during SARS-CoV-2 infection independently of its severity or the patient´s atopic history." @default.
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- W4210314573 date "2022-02-01" @default.
- W4210314573 modified "2023-10-06" @default.
- W4210314573 title "Exhaled nitric oxide is decreased in Sars-Cov-2 infection" @default.
- W4210314573 doi "https://doi.org/10.1016/j.jaci.2021.12.354" @default.
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