Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210316095> ?p ?o ?g. }
- W4210316095 abstract "Abstract Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of the aberrant immune response have been investigated, comprehensive studies linking different data layers are lacking. Using an integrated systems immunology approach, we evaluated neutrophil phenotypes and concomitant changes in cytokines and metabolites in sepsis patients. Our findings identify novel differentially expressed immature neutrophil subsets in sepsis patients. These and other subsets correlate with various proteins, metabolites, and lipids, including pentraxin-3, angiopoietin-2 and lysophosphatidylcholines, in sepsis patients. These results enabled the construction of a predictive model based on weighted multi-omics linear regression analysis for patient classification. These findings could help inform earlier patient stratification and treatment options, as well as facilitate future mechanistic studies targeting the trifecta of surface marker expression, cytokines, and metabolites." @default.
- W4210316095 created "2022-02-08" @default.
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- W4210316095 date "2022-02-04" @default.
- W4210316095 modified "2023-10-16" @default.
- W4210316095 title "Novel neutrophil subsets associated with sepsis, vascular dysfunction and metabolic alterations identified using systems immunology" @default.
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