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- W4210318150 abstract "Systemic interferon has been advocated as an effective therapy for recurrent genital warts. A double-blind, placebo-controlled, multicenter international trial involving 172 patients with recurrent condylomata was conducted using systemic interferon alfa-2a in doses of 3 or 9 MIU three times per week for 4 weeks. The treatment period was followed by a treatment-free follow-up period of 2 months. Complete responders at month 3 were followed up to 9 months or until they had a recurrence, whichever occurred first. The combined rates of complete response (total disappearance of all lesions without appearance of new ones) and major incomplete response (at least a 75% reduction in total lesion area) at 3 months after the commencement of therapy were 34%, 25%, and 30%, respectively, in 166 patients receiving 3 and 9 MIU of interferon alfa-2a and placebo. The recurrence rates at the end of 9 months were 9% in the placebo and 3-MIU groups and 36% in the 9-MIU group. We conclude that systemic interferon alfa-2a administered three times weekly for 4 weeks at doses of 3 and 9 MIU is not effective as monotherapy for genital warts that have recurred after standard ablative therapy. (<i>JAMA</i>. 1991;265:2684-2687)" @default.
- W4210318150 created "2022-02-08" @default.
- W4210318150 date "1991-05-22" @default.
- W4210318150 modified "2023-10-18" @default.
- W4210318150 title "Recurrent Condylomata Acuminata Treated With Recombinant Interferon Alfa-2a" @default.
- W4210318150 doi "https://doi.org/10.1001/jama.1991.03460200064036" @default.
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