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- W4210330147 endingPage "79" @default.
- W4210330147 startingPage "55" @default.
- W4210330147 abstract "The capacity of cyanobacteria to produce compounds that affect physiological processes in humans is well documented, and their potential beneficial uses have been thoroughly investigated. Anticancer treatment is a field where cyanobacterial compounds could play an important role. Many drugs used in cancer therapy derive from natural products, and cyanobacterial compounds could be a valuable addition to the arsenal of anticancer drugs. In this chapter, our emphasis will be put on cyanobacterial compounds which have been, or are being tested in clinical trials. We focus on the dolastatins and cryptophycins, since these have been tested extensively, but also because these have been further developed into anticancer treatments using dedicated drug carriers, so-called antibody-drug conjugates. These represent an efficient way to improve the properties of drug candidates, which may otherwise be unsuited due to unacceptable toxicity profile, or poor pharmacokinetics. We will also briefly discuss some challenges in anticancer drug development." @default.
- W4210330147 created "2022-02-08" @default.
- W4210330147 creator A5074184113 @default.
- W4210330147 creator A5081187407 @default.
- W4210330147 date "2022-01-01" @default.
- W4210330147 modified "2023-09-25" @default.
- W4210330147 title "Cyanobacterial anticancer compounds in clinical use: Lessons from the dolastatins and cryptophycins" @default.
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