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- W4210335265 abstract "Abstract The first realization of the amino‐trimethylenemethane chemistry is reported using a deprotonation strategy to simplify the synthesis of the amino‐trimethylenemethane donor in two steps from commercial and inexpensive materials. A broad scope of cycloaddition acceptors (seven different classes) participated in the chemistry, chemo‐, regio‐, diastereo‐, and enantioselectively generating various types of highly valuable complex amino cycles. Multiple derivatization reactions that further elaborated the initial amino cycles were performed without isolation of the crude product. Ultimately, we applied the amino‐trimethylenemethane chemistry to synthesize a potential pharmaceutical in 8 linear steps and 7.5 % overall yield, which previously was achieved in 18 linear steps and 0.6 % overall yield." @default.
- W4210335265 created "2022-02-08" @default.
- W4210335265 creator A5032412691 @default.
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- W4210335265 date "2018-07-18" @default.
- W4210335265 modified "2023-10-14" @default.
- W4210335265 title "A Deprotonation Approach to the Unprecedented Amino‐Trimethylenemethane Chemistry: Regio‐, Diastereo‐, and Enantioselective Synthesis of Complex Amino Cycles" @default.
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- W4210335265 doi "https://doi.org/10.1002/ange.201805876" @default.
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