Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210339973> ?p ?o ?g. }
- W4210339973 abstract "Alzheimer's Disease (AD) is a neurodegenerative disorder that is still not fully understood. Sex modifies AD vulnerability, but the reasons for this are largely unknown. We utilize two independent electronic medical record (EMR) systems across 44,288 patients to perform deep clinical phenotyping and network analysis to gain insight into clinical characteristics and sex-specific clinical associations in AD. Embeddings and network representation of patient diagnoses demonstrate greater comorbidity interactions in AD in comparison to matched controls. Enrichment analysis identifies multiple known and new diagnostic, medication, and lab result associations across the whole cohort and in a sex-stratified analysis. With this data-driven method of phenotyping, we can represent AD complexity and generate hypotheses of clinical factors that can be followed-up for further diagnostic and predictive analyses, mechanistic understanding, or drug repurposing and therapeutic approaches." @default.
- W4210339973 created "2022-02-08" @default.
- W4210339973 creator A5003553217 @default.
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- W4210339973 creator A5086033147 @default.
- W4210339973 date "2022-02-03" @default.
- W4210339973 modified "2023-10-18" @default.
- W4210339973 title "Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations" @default.
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