Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210341244> ?p ?o ?g. }
- W4210341244 endingPage "361" @default.
- W4210341244 startingPage "350" @default.
- W4210341244 abstract "Ionising radiation exposure of 5-10gray (Gy) to the pelvic area induces premature ovarian failure (POF). Twenty-four young adult Wistar albino female rats were were treated with subcutaneous capsaicin 0.5mg/kg per day or placebo for 10days then exposed to whole body irradiation. Rats were randomly divided into four groups: (1) control; (2) capsaicin; (3) radiation only (IR): rats were injected with placebo before exposure to a single dose of 8.3-Gy whole body irradiation; (4) radiation-capsaicin (IR+CAP): rats were injected with capsaicin prior to whole body irradiation. Radiation triggered oxidative stress, increased ovarian inflammation, increased follicular apoptosis and diminished ovarian follicle pool. Capsaicin significantly ameliorated oxidative stress by decreasing serum total oxidant status, oxidative stress index, disulphide, and malondialdehyde levels (P ≤0.001); ovarian inflammatory status by decreasing expressions of TNF-α, IL-1β, PARP-1 (P =0.002); apoptosis by decreasing expressions of active caspase-3 and p53 (P =0.015, P =0.002); and follicle counts by increasing primordial follicles and decreasing apoptotic follicles (P ≤0.001) in rats when administered before radiation exposure. The beneficial effects of capsaicin are demonstrated for the first time on ionising radiation exposed rat ovaries. Capsaicin pre-treatment before radiotherapy restores the primordial follicle pool, inhibits atresia of ovarian follicles and may be an acceptable therapeutic modality to prevent radiation-induced POF." @default.
- W4210341244 created "2022-02-08" @default.
- W4210341244 creator A5023547726 @default.
- W4210341244 creator A5033710261 @default.
- W4210341244 creator A5036619376 @default.
- W4210341244 creator A5051661361 @default.
- W4210341244 creator A5055487039 @default.
- W4210341244 creator A5058226199 @default.
- W4210341244 creator A5081064264 @default.
- W4210341244 date "2022-02-01" @default.
- W4210341244 modified "2023-09-23" @default.
- W4210341244 title "Capsaicin prevents radiotherapy-induced premature ovarian failure in rats" @default.
- W4210341244 cites W1590457525 @default.
- W4210341244 cites W1969093811 @default.
- W4210341244 cites W1976464405 @default.
- W4210341244 cites W1982209289 @default.
- W4210341244 cites W1983498344 @default.
- W4210341244 cites W1989877184 @default.
- W4210341244 cites W2004274286 @default.
- W4210341244 cites W2012879076 @default.
- W4210341244 cites W2051639904 @default.
- W4210341244 cites W2075052934 @default.
- W4210341244 cites W2077763928 @default.
- W4210341244 cites W2079705639 @default.
- W4210341244 cites W2087209804 @default.
- W4210341244 cites W2093825455 @default.
- W4210341244 cites W2107630189 @default.
- W4210341244 cites W2108536849 @default.
- W4210341244 cites W2114798374 @default.
- W4210341244 cites W2127382664 @default.
- W4210341244 cites W2139348009 @default.
- W4210341244 cites W2142743678 @default.
- W4210341244 cites W2143476211 @default.
- W4210341244 cites W2146354194 @default.
- W4210341244 cites W2151213561 @default.
- W4210341244 cites W2171847928 @default.
- W4210341244 cites W2203934057 @default.
- W4210341244 cites W2288343858 @default.
- W4210341244 cites W2341003410 @default.
- W4210341244 cites W2582611611 @default.
- W4210341244 cites W2592818525 @default.
- W4210341244 cites W2606197115 @default.
- W4210341244 cites W2616470853 @default.
- W4210341244 cites W2789215127 @default.
- W4210341244 cites W2803303442 @default.
- W4210341244 cites W2912853410 @default.
- W4210341244 cites W2920853967 @default.
- W4210341244 cites W2940313881 @default.
- W4210341244 cites W2945695834 @default.
- W4210341244 cites W2969328838 @default.
- W4210341244 cites W3022352482 @default.
- W4210341244 cites W3048544241 @default.
- W4210341244 cites W3082022870 @default.
- W4210341244 cites W3111570320 @default.
- W4210341244 cites W3151267789 @default.
- W4210341244 doi "https://doi.org/10.1071/rd21235" @default.
- W4210341244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35101163" @default.
- W4210341244 hasPublicationYear "2022" @default.
- W4210341244 type Work @default.
- W4210341244 citedByCount "2" @default.
- W4210341244 countsByYear W42103412442023 @default.
- W4210341244 crossrefType "journal-article" @default.
- W4210341244 hasAuthorship W4210341244A5023547726 @default.
- W4210341244 hasAuthorship W4210341244A5033710261 @default.
- W4210341244 hasAuthorship W4210341244A5036619376 @default.
- W4210341244 hasAuthorship W4210341244A5051661361 @default.
- W4210341244 hasAuthorship W4210341244A5055487039 @default.
- W4210341244 hasAuthorship W4210341244A5058226199 @default.
- W4210341244 hasAuthorship W4210341244A5081064264 @default.
- W4210341244 hasConcept C102570824 @default.
- W4210341244 hasConcept C104317684 @default.
- W4210341244 hasConcept C126322002 @default.
- W4210341244 hasConcept C134018914 @default.
- W4210341244 hasConcept C142724271 @default.
- W4210341244 hasConcept C170493617 @default.
- W4210341244 hasConcept C185592680 @default.
- W4210341244 hasConcept C190283241 @default.
- W4210341244 hasConcept C204787440 @default.
- W4210341244 hasConcept C27081682 @default.
- W4210341244 hasConcept C2776151105 @default.
- W4210341244 hasConcept C2776914184 @default.
- W4210341244 hasConcept C2777216303 @default.
- W4210341244 hasConcept C2777395788 @default.
- W4210341244 hasConcept C2778182776 @default.
- W4210341244 hasConcept C2778324911 @default.
- W4210341244 hasConcept C2778401633 @default.
- W4210341244 hasConcept C2780051329 @default.
- W4210341244 hasConcept C2780536345 @default.
- W4210341244 hasConcept C5512455 @default.
- W4210341244 hasConcept C55493867 @default.
- W4210341244 hasConcept C71924100 @default.
- W4210341244 hasConcept C87073359 @default.
- W4210341244 hasConceptScore W4210341244C102570824 @default.
- W4210341244 hasConceptScore W4210341244C104317684 @default.
- W4210341244 hasConceptScore W4210341244C126322002 @default.
- W4210341244 hasConceptScore W4210341244C134018914 @default.
- W4210341244 hasConceptScore W4210341244C142724271 @default.
- W4210341244 hasConceptScore W4210341244C170493617 @default.