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- W4210343885 abstract "MicroRNAs (miRNAs) are small non-coding RNAs, which play important roles in regulating various biological functions. Many available miRNA databases have provided a large number of valuable resources for miRNA investigation. However, not all existing databases provide comprehensive information regarding the transcriptional regulatory regions of miRNAs, especially typical enhancer, super-enhancer (SE), and chromatin accessibility regions. An increasing number of studies have shown that the transcriptional regulatory regions of miRNAs, as well as related single-nucleotide polymorphisms (SNPs) and transcription factors (TFs) have a strong influence on human diseases and biological processes. Here, we developed a comprehensive database for the human transcriptional regulation of miRNAs (TRmir), which is focused on providing a wealth of available resources regarding the transcriptional regulatory regions of miRNAs and annotating their potential roles in the regulation of miRNAs. TRmir contained a total of 5,754,414 typical enhancers/SEs and 1,733,966 chromatin accessibility regions associated with 1,684 human miRNAs. These regions were identified from over 900 human H3K27ac ChIP-seq, ATAC-seq, and DNase-seq samples. Furthermore, TRmir provided detailed (epi)genetic information about the transcriptional regulatory regions of miRNAs, including TFs, common SNPs, risk SNPs, linkage disequilibrium (LD) SNPs, expression quantitative trait loci (eQTLs), 3D chromatin interactions, and methylation sites, especially supporting the display of TF binding sites in the regulatory regions of over 7,000 TF ChIP-seq samples. In addition, TRmir integrated miRNA expression and related disease information, supporting extensive pathway analysis. TRmir is a powerful platform that offers comprehensive information about the transcriptional regulation of miRNAs for users and provides detailed annotations of regulatory regions. TRmir is free for academic users and can be accessed at http://bio.liclab.net/trmir/index.html." @default.
- W4210343885 created "2022-02-08" @default.
- W4210343885 creator A5001492813 @default.
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- W4210343885 date "2022-02-04" @default.
- W4210343885 modified "2023-10-18" @default.
- W4210343885 title "TRmir: A Comprehensive Resource for Human Transcriptional Regulatory Information of MiRNAs" @default.
- W4210343885 cites W1648301895 @default.
- W4210343885 cites W1964733653 @default.
- W4210343885 cites W1971578941 @default.
- W4210343885 cites W1986223165 @default.
- W4210343885 cites W1990678336 @default.
- W4210343885 cites W2003878536 @default.
- W4210343885 cites W2004966039 @default.
- W4210343885 cites W2016015848 @default.
- W4210343885 cites W2026690931 @default.
- W4210343885 cites W2027650876 @default.
- W4210343885 cites W2030166934 @default.
- W4210343885 cites W2030888171 @default.
- W4210343885 cites W2037589121 @default.
- W4210343885 cites W2039572187 @default.
- W4210343885 cites W2042027879 @default.
- W4210343885 cites W2053835153 @default.
- W4210343885 cites W2060484997 @default.
- W4210343885 cites W2064586774 @default.
- W4210343885 cites W2070571588 @default.
- W4210343885 cites W2072698217 @default.
- W4210343885 cites W2080152736 @default.
- W4210343885 cites W2084160423 @default.
- W4210343885 cites W2090648161 @default.
- W4210343885 cites W2094678200 @default.
- W4210343885 cites W2099698839 @default.
- W4210343885 cites W2102619694 @default.
- W4210343885 cites W2112192177 @default.
- W4210343885 cites W2113100102 @default.
- W4210343885 cites W2113974339 @default.
- W4210343885 cites W2114097410 @default.
- W4210343885 cites W2116868464 @default.
- W4210343885 cites W2121284504 @default.
- W4210343885 cites W2122732537 @default.
- W4210343885 cites W2123411711 @default.
- W4210343885 cites W2124985265 @default.
- W4210343885 cites W2126305708 @default.
- W4210343885 cites W2127640118 @default.
- W4210343885 cites W2133658633 @default.
- W4210343885 cites W2140952049 @default.
- W4210343885 cites W2145010689 @default.
- W4210343885 cites W2149992227 @default.
- W4210343885 cites W2150536104 @default.
- W4210343885 cites W2156627746 @default.
- W4210343885 cites W2157009395 @default.
- W4210343885 cites W2158135353 @default.
- W4210343885 cites W2161633633 @default.
- W4210343885 cites W2171808845 @default.
- W4210343885 cites W2173754487 @default.
- W4210343885 cites W2248907500 @default.
- W4210343885 cites W2254523062 @default.
- W4210343885 cites W2259938310 @default.
- W4210343885 cites W2335852140 @default.
- W4210343885 cites W2336957559 @default.
- W4210343885 cites W2513739312 @default.
- W4210343885 cites W2518703062 @default.
- W4210343885 cites W2534008312 @default.
- W4210343885 cites W2537679995 @default.
- W4210343885 cites W2544405043 @default.
- W4210343885 cites W2560905785 @default.
- W4210343885 cites W2574266062 @default.
- W4210343885 cites W2588025094 @default.
- W4210343885 cites W2593459113 @default.
- W4210343885 cites W2743444862 @default.
- W4210343885 cites W2760366406 @default.
- W4210343885 cites W2765683665 @default.
- W4210343885 cites W2766421346 @default.
- W4210343885 cites W2767546566 @default.
- W4210343885 cites W2767743008 @default.
- W4210343885 cites W2768632638 @default.
- W4210343885 cites W2768781242 @default.
- W4210343885 cites W2769428789 @default.
- W4210343885 cites W2772545773 @default.
- W4210343885 cites W2793081232 @default.
- W4210343885 cites W2805684402 @default.
- W4210343885 cites W2891085660 @default.
- W4210343885 cites W2897825874 @default.
- W4210343885 cites W2898215009 @default.
- W4210343885 cites W2898280147 @default.
- W4210343885 cites W2899510892 @default.
- W4210343885 cites W2910305771 @default.
- W4210343885 cites W2913966972 @default.