FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210344810> ?p ?o ?g. }

• W4210344810 abstract "The formation and functioning of muscles are fundamental aspects of animal biology, and the evolution of 'muscle genes' is central to our understanding of this tissue. Feeding-fasting-refeeding experiments have been widely used to assess muscle cellular and metabolic responses to nutrition. Though these studies have focused on vertebrate models and only a few invertebrate systems, they have found similar processes are involved in muscle degradation and maintenance. Motivation for these studies stems from interest in diseases whose pathologies involve muscle atrophy, a symptom also triggered by fasting, as well as commercial interest in the muscle mass of animals kept for consumption. Experimentally modelling atrophy by manipulating nutritional state causes muscle mass to be depleted during starvation and replenished with refeeding so that the genetic mechanisms controlling muscle growth and degradation can be understood.Using amphioxus, the earliest branching chordate lineage, we address the gap in previous work stemming from comparisons between distantly related vertebrate and invertebrate models. Our amphioxus feeding-fasting-refeeding muscle transcriptomes reveal a highly conserved myogenic program and that the pro-orthologues of many vertebrate myoblast fusion genes were present in the ancestral chordate, despite these invertebrate chordates having unfused mononucleate myocytes. We found that genes differentially expressed between fed and fasted amphioxus were orthologous to the genes that respond to nutritional state in vertebrates. This response is driven in a large part by the highly conserved IGF/Akt/FOXO pathway, where depleted nutrient levels result in activation of FOXO, a transcription factor with many autophagy-related gene targets.Reconstruction of these gene networks and pathways in amphioxus muscle provides a key point of comparison between the distantly related groups assessed thus far, significantly refining the reconstruction of the ancestral state for chordate myoblast fusion genes and identifying the extensive role of duplicated genes in the IGF/Akt/FOXO pathway across animals. Our study elucidates the evolutionary trajectory of muscle genes as they relate to the increased complexity of vertebrate muscles and muscle development." @default.
• W4210344810 created "2022-02-08" @default.
• W4210344810 creator A5030117329 @default.
• W4210344810 creator A5042635096 @default.
• W4210344810 creator A5086873853 @default.
• W4210344810 date "2022-02-01" @default.
• W4210344810 modified "2023-10-14" @default.
• W4210344810 title "Amphioxus muscle transcriptomes reveal vertebrate-like myoblast fusion genes and a highly conserved role of insulin signalling in the metabolism of muscle" @default.
• W4210344810 cites W139001593 @default.
• W4210344810 cites W1515707502 @default.
• W4210344810 cites W1631908837 @default.
• W4210344810 cites W1768818798 @default.
• W4210344810 cites W18105833 @default.
• W4210344810 cites W1898922522 @default.
• W4210344810 cites W1923477899 @default.
• W4210344810 cites W1966040173 @default.
• W4210344810 cites W1968095594 @default.
• W4210344810 cites W1969650180 @default.
• W4210344810 cites W1971857747 @default.
• W4210344810 cites W1972448893 @default.
• W4210344810 cites W1972597570 @default.
• W4210344810 cites W1974093434 @default.
• W4210344810 cites W1980850880 @default.
• W4210344810 cites W1981426060 @default.
• W4210344810 cites W1991476773 @default.
• W4210344810 cites W1992427679 @default.
• W4210344810 cites W1994895188 @default.
• W4210344810 cites W1997355536 @default.
• W4210344810 cites W1999574084 @default.
• W4210344810 cites W2001878184 @default.
• W4210344810 cites W2001969764 @default.
• W4210344810 cites W2003141932 @default.
• W4210344810 cites W2004324027 @default.
• W4210344810 cites W2004966843 @default.
• W4210344810 cites W2009100350 @default.
• W4210344810 cites W2009278300 @default.
• W4210344810 cites W2009412340 @default.
• W4210344810 cites W2009856397 @default.
• W4210344810 cites W2009886463 @default.
• W4210344810 cites W2010814798 @default.
• W4210344810 cites W2011485425 @default.
• W4210344810 cites W2013317474 @default.
• W4210344810 cites W2014593313 @default.
• W4210344810 cites W2015281828 @default.
• W4210344810 cites W2017969831 @default.
• W4210344810 cites W2018685959 @default.
• W4210344810 cites W2018768258 @default.
• W4210344810 cites W2019591778 @default.
• W4210344810 cites W2020585063 @default.
• W4210344810 cites W2023844437 @default.
• W4210344810 cites W2024575313 @default.
• W4210344810 cites W2025192214 @default.
• W4210344810 cites W2025786074 @default.
• W4210344810 cites W2028302194 @default.
• W4210344810 cites W2028957323 @default.
• W4210344810 cites W2029807419 @default.
• W4210344810 cites W2031078895 @default.
• W4210344810 cites W2032035791 @default.
• W4210344810 cites W2032427485 @default.
• W4210344810 cites W2033682352 @default.
• W4210344810 cites W2033797333 @default.
• W4210344810 cites W2034490215 @default.
• W4210344810 cites W2036145275 @default.
• W4210344810 cites W2036676468 @default.
• W4210344810 cites W2037341437 @default.
• W4210344810 cites W203969555 @default.
• W4210344810 cites W2041612616 @default.
• W4210344810 cites W2042195196 @default.
• W4210344810 cites W2045393678 @default.
• W4210344810 cites W2046499301 @default.
• W4210344810 cites W2046623154 @default.
• W4210344810 cites W2046982221 @default.
• W4210344810 cites W2047090435 @default.
• W4210344810 cites W2047405437 @default.
• W4210344810 cites W2049164900 @default.
• W4210344810 cites W2049485508 @default.
• W4210344810 cites W2049715648 @default.
• W4210344810 cites W2050020730 @default.
• W4210344810 cites W2050376717 @default.
• W4210344810 cites W2053927358 @default.
• W4210344810 cites W2057860337 @default.
• W4210344810 cites W2059055543 @default.
• W4210344810 cites W2062336149 @default.
• W4210344810 cites W2063443397 @default.
• W4210344810 cites W2066727453 @default.
• W4210344810 cites W2073720580 @default.
• W4210344810 cites W2073963703 @default.
• W4210344810 cites W2077875518 @default.
• W4210344810 cites W2080239160 @default.
• W4210344810 cites W2081305406 @default.
• W4210344810 cites W2082115260 @default.
• W4210344810 cites W2082416335 @default.
• W4210344810 cites W2085107051 @default.
• W4210344810 cites W2087085892 @default.
• W4210344810 cites W2087335829 @default.
• W4210344810 cites W2096124496 @default.
• W4210344810 cites W2097794398 @default.
• W4210344810 cites W2103503054 @default.
• W4210344810 cites W2104097983 @default.
• W4210344810 cites W2109488005 @default.

• next