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- W4210346695 abstract "Abstract A chemobiocatalytic strategy for the highly stereoselective synthesis of nitrile‐substituted cyclopropanes is reported. The present approach relies on an asymmetric olefin cyclopropanation reaction catalyzed by an engineered myoglobin in the presence of ex situ generated diazoacetonitrile within a compartmentalized reaction system. This method enabled the efficient transformation of a broad range of olefin substrates at a preparative scale with up to 99.9 % de and ee and up to 5600 turnovers. The enzymatic product could be further elaborated to afford a variety of functionalized chiral cyclopropanes. This work expands the range of synthetically valuable, abiotic transformations accessible through biocatalysis and paves the way to the practical and safe exploitation of diazoacetonitrile in biocatalytic carbene transfer reactions." @default.
- W4210346695 created "2022-02-08" @default.
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- W4210346695 date "2018-11-05" @default.
- W4210346695 modified "2023-10-15" @default.
- W4210346695 title "Highly Diastereo‐ and Enantioselective Synthesis of Nitrile‐Substituted Cyclopropanes by Myoglobin‐Mediated Carbene Transfer Catalysis" @default.
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- W4210346695 doi "https://doi.org/10.1002/ange.201810059" @default.
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