FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210347367> ?p ?o ?g. }

• W4210347367 endingPage "97" @default.
• W4210347367 startingPage "82" @default.
• W4210347367 abstract "Mitochondrial dysfunction, oxidative stress and misfolded protein aggregation are related to autophagy-lysosomal dysregulation and contribute to the pathogenesis of Parkinson' s disease (PD). ZKSCAN3, a transcriptional repressor, plays a crucial role in autophagy and lysosomal biogenesis. However, the role and modification of ZKSCAN3 in the defection of ALP, along with the molecular mechanism involved in pathogenesis of PD, still remain unclear. In this study, we demonstrated that cellular reactive oxygen species (ROS) generated by MPP+ exposure and the resulting oxidative damage were counteracted by SIRT1-ZKSCAN3 pathway induction. Here we showed that nuclear ZKSCAN3 significantly increased in ventral midbrain of MPTP-treated mice and MPP+-treated SN4741 cells. Knockdown of ZKSCAN3 alleviated MPP+-induced ALP defect, Tyrosine Hydroxylase (TH) declination and neuronal death. NAC, a ROS scavenger, reduced the nuclear translocation of ZKSCAN3 and sequentially improved ALP function in MPP+-treated SN4741 cells. SRT2104, a SIRT1 activator, attenuated impairment of ALP in MPP+-treated SN47417 cells through decreasing nuclear accumulation of ZKSCAN3 and protected dopaminergic neurons from MPTP injury. Moreover, SRT2104 relieved impairment in locomotor activities and coordination skills upon treatment of MPTP in C57/BL6J mice through behavior tests including rotarod, pole climbing and grid. Furthermore, ZKSCAN3 was a novel substrate of SIRT1 which was deacetylated at lysine 148 residues by SIRT1. This subsequently facilitated the shuttling of ZKSCAN3 to the cytoplasm. Therefore, our study identifies a novel acetylation-dependent regulatory mechanism of nuclear translocation of ZKSCAN3. It results in autophagy-lysosomal dysfunction and then leads to DA neuronal death in MPTP/MPP+ model of PD." @default.
• W4210347367 created "2022-02-08" @default.
• W4210347367 creator A5013509330 @default.
• W4210347367 creator A5015934725 @default.
• W4210347367 creator A5020374246 @default.
• W4210347367 creator A5024446633 @default.
• W4210347367 creator A5025712098 @default.
• W4210347367 creator A5034292235 @default.
• W4210347367 creator A5067650316 @default.
• W4210347367 creator A5089742379 @default.
• W4210347367 date "2022-03-01" @default.
• W4210347367 modified "2023-10-15" @default.
• W4210347367 title "Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP+-induced oxidative stress" @default.
• W4210347367 cites W1896092673 @default.
• W4210347367 cites W1975200363 @default.
• W4210347367 cites W1975619206 @default.
• W4210347367 cites W2002671660 @default.
• W4210347367 cites W2019551137 @default.
• W4210347367 cites W2022911097 @default.
• W4210347367 cites W2041231665 @default.
• W4210347367 cites W2045970460 @default.
• W4210347367 cites W2048884200 @default.
• W4210347367 cites W2058074769 @default.
• W4210347367 cites W2063899405 @default.
• W4210347367 cites W2072361357 @default.
• W4210347367 cites W2079355772 @default.
• W4210347367 cites W2096145019 @default.
• W4210347367 cites W2102614059 @default.
• W4210347367 cites W2111198102 @default.
• W4210347367 cites W2114900293 @default.
• W4210347367 cites W2117119983 @default.
• W4210347367 cites W2141483618 @default.
• W4210347367 cites W2280212630 @default.
• W4210347367 cites W2293027573 @default.
• W4210347367 cites W2404007189 @default.
• W4210347367 cites W2425597023 @default.
• W4210347367 cites W2478966229 @default.
• W4210347367 cites W2511725062 @default.
• W4210347367 cites W2520973513 @default.
• W4210347367 cites W2586594127 @default.
• W4210347367 cites W2587142564 @default.
• W4210347367 cites W2605252223 @default.
• W4210347367 cites W2607117132 @default.
• W4210347367 cites W2615322840 @default.
• W4210347367 cites W2622186113 @default.
• W4210347367 cites W2628638289 @default.
• W4210347367 cites W2739830864 @default.
• W4210347367 cites W2765958844 @default.
• W4210347367 cites W2768651887 @default.
• W4210347367 cites W2803182333 @default.
• W4210347367 cites W2804009775 @default.
• W4210347367 cites W2804970493 @default.
• W4210347367 cites W2808972879 @default.
• W4210347367 cites W2811095894 @default.
• W4210347367 cites W2913930171 @default.
• W4210347367 cites W2915829463 @default.
• W4210347367 cites W2921886188 @default.
• W4210347367 cites W2937680741 @default.
• W4210347367 cites W2983911660 @default.
• W4210347367 cites W2998617214 @default.
• W4210347367 cites W3015095871 @default.
• W4210347367 cites W3044530738 @default.
• W4210347367 cites W3049705534 @default.
• W4210347367 cites W3096181504 @default.
• W4210347367 cites W3129543960 @default.
• W4210347367 cites W4211123396 @default.
• W4210347367 doi "https://doi.org/10.1016/j.freeradbiomed.2022.02.001" @default.
• W4210347367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35124181" @default.
• W4210347367 hasPublicationYear "2022" @default.
• W4210347367 type Work @default.
• W4210347367 citedByCount "7" @default.
• W4210347367 countsByYear W42103473672023 @default.
• W4210347367 crossrefType "journal-article" @default.
• W4210347367 hasAuthorship W4210347367A5013509330 @default.
• W4210347367 hasAuthorship W4210347367A5015934725 @default.
• W4210347367 hasAuthorship W4210347367A5020374246 @default.
• W4210347367 hasAuthorship W4210347367A5024446633 @default.
• W4210347367 hasAuthorship W4210347367A5025712098 @default.
• W4210347367 hasAuthorship W4210347367A5034292235 @default.
• W4210347367 hasAuthorship W4210347367A5067650316 @default.
• W4210347367 hasAuthorship W4210347367A5089742379 @default.
• W4210347367 hasConcept C104317684 @default.
• W4210347367 hasConcept C127561419 @default.
• W4210347367 hasConcept C137183658 @default.
• W4210347367 hasConcept C169760540 @default.
• W4210347367 hasConcept C185592680 @default.
• W4210347367 hasConcept C190283241 @default.
• W4210347367 hasConcept C203522944 @default.
• W4210347367 hasConcept C2776151105 @default.
• W4210347367 hasConcept C2776536020 @default.
• W4210347367 hasConcept C2776804853 @default.
• W4210347367 hasConcept C2778674702 @default.
• W4210347367 hasConcept C2779324830 @default.
• W4210347367 hasConcept C31573885 @default.
• W4210347367 hasConcept C48349386 @default.
• W4210347367 hasConcept C513476851 @default.
• W4210347367 hasConcept C55493867 @default.
• W4210347367 hasConcept C86803240 @default.

• next