Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210351709> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4210351709 abstract "We describe a palladium catalyzed non-directed late-stage deuteration of arenes. Key aspects include the use of D2O as a convenient and easily available deuterium source and the discovery of highly active N,N-bidentate ligands containing an N-acyl sulfonamide group. The reported protocol enables high degrees of deuterium incorporation via a reversible C-H activation step and features an extraordinary functional group tolerance, allowing for the deuteration of complex substrates. This is exemplified by the late-stage isotopic labelling of various pharmaceutically relevant motifs and related scaffolds. We expect that this method, amongst other applications, will prove useful as a tool in drug development processes and for mechanistic studies." @default.
- W4210351709 created "2022-02-08" @default.
- W4210351709 creator A5032843034 @default.
- W4210351709 creator A5038275107 @default.
- W4210351709 creator A5040452398 @default.
- W4210351709 creator A5075471858 @default.
- W4210351709 creator A5082979214 @default.
- W4210351709 date "2021-08-06" @default.
- W4210351709 modified "2023-09-24" @default.
- W4210351709 title "Palladium-Catalyzed Late-Stage C-H Deuteration of Arenes" @default.
- W4210351709 doi "https://doi.org/10.26434/chemrxiv-2021-vtsnn" @default.
- W4210351709 hasPublicationYear "2021" @default.
- W4210351709 type Work @default.
- W4210351709 citedByCount "0" @default.
- W4210351709 crossrefType "posted-content" @default.
- W4210351709 hasAuthorship W4210351709A5032843034 @default.
- W4210351709 hasAuthorship W4210351709A5038275107 @default.
- W4210351709 hasAuthorship W4210351709A5040452398 @default.
- W4210351709 hasAuthorship W4210351709A5075471858 @default.
- W4210351709 hasAuthorship W4210351709A5082979214 @default.
- W4210351709 hasBestOaLocation W42103517091 @default.
- W4210351709 hasConcept C121332964 @default.
- W4210351709 hasConcept C161790260 @default.
- W4210351709 hasConcept C178516000 @default.
- W4210351709 hasConcept C178790620 @default.
- W4210351709 hasConcept C185592680 @default.
- W4210351709 hasConcept C21951064 @default.
- W4210351709 hasConcept C2777332933 @default.
- W4210351709 hasConcept C2781039511 @default.
- W4210351709 hasConcept C502130503 @default.
- W4210351709 hasConcept C521977710 @default.
- W4210351709 hasConcept C544153396 @default.
- W4210351709 hasConcept C58364064 @default.
- W4210351709 hasConcept C62520636 @default.
- W4210351709 hasConcept C71240020 @default.
- W4210351709 hasConceptScore W4210351709C121332964 @default.
- W4210351709 hasConceptScore W4210351709C161790260 @default.
- W4210351709 hasConceptScore W4210351709C178516000 @default.
- W4210351709 hasConceptScore W4210351709C178790620 @default.
- W4210351709 hasConceptScore W4210351709C185592680 @default.
- W4210351709 hasConceptScore W4210351709C21951064 @default.
- W4210351709 hasConceptScore W4210351709C2777332933 @default.
- W4210351709 hasConceptScore W4210351709C2781039511 @default.
- W4210351709 hasConceptScore W4210351709C502130503 @default.
- W4210351709 hasConceptScore W4210351709C521977710 @default.
- W4210351709 hasConceptScore W4210351709C544153396 @default.
- W4210351709 hasConceptScore W4210351709C58364064 @default.
- W4210351709 hasConceptScore W4210351709C62520636 @default.
- W4210351709 hasConceptScore W4210351709C71240020 @default.
- W4210351709 hasLocation W42103517091 @default.
- W4210351709 hasOpenAccess W4210351709 @default.
- W4210351709 hasPrimaryLocation W42103517091 @default.
- W4210351709 hasRelatedWork W14595213 @default.
- W4210351709 hasRelatedWork W17974049 @default.
- W4210351709 hasRelatedWork W24062709 @default.
- W4210351709 hasRelatedWork W28516499 @default.
- W4210351709 hasRelatedWork W28722446 @default.
- W4210351709 hasRelatedWork W30014162 @default.
- W4210351709 hasRelatedWork W35478014 @default.
- W4210351709 hasRelatedWork W35779890 @default.
- W4210351709 hasRelatedWork W4442095 @default.
- W4210351709 hasRelatedWork W7907452 @default.
- W4210351709 isParatext "false" @default.
- W4210351709 isRetracted "false" @default.
- W4210351709 workType "article" @default.