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- W4210360418 abstract "Abstract Background Black cumin ( Nigella sativa ) is a widely used ingredient of traditional medicine for its broad-spectrum pharmacological actions, including analgesic, bronchial asthma, anti-inflammatory properties, and others. We sought to evaluate BC extracts' efficacy for the anti-inflammatory and analgesic properties using a comprehensive in vivo and in silico experimental setup. To investigate whether BC extract has anti-inflammatory and analgesic therapeutic potentials in vivo anti-inflammatory activity by carrageenan-induced rat paw edema, analgesic activity by acetic acid-induced writhing test and ingenuity analysis of the BC extracts in inflammation control. Results The acetic acid-induced writhing test had shown a dose-dependent reduction of writhing number following BC administration. Rat paw edema test showed the dose-dependent reduction of paw edema volume following BC administration. Ingenuity Pathway Analysis (IPA) suggested BC extracts containing ferulic acid, p-coumaric acid, kaempferol, and quercetin can inhibit inflammation. Conclusions This study suggests that bioactive compounds in BC extract act as an anti-inflammatory and analgesic agent by regulating several downstream and upstream inflammation pathways." @default.
- W4210360418 created "2022-02-08" @default.
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- W4210360418 date "2022-02-02" @default.
- W4210360418 modified "2023-10-16" @default.
- W4210360418 title "Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems" @default.
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- W4210360418 doi "https://doi.org/10.1186/s42269-022-00708-0" @default.
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