Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210361229> ?p ?o ?g. }
- W4210361229 abstract "ABSTRACT To understand the genetic basis in governing phosphorus (P) acquisition, we performed genome-wide association studies (GWAS) on a diversity panel of Arabidopsis thaliana by two primary determinants of P acquisition, phosphate (Pi)-uptake activity and PHOSPHATE TRANSPORTER 1 (PHT1) protein abundance. Association mapping revealed a shared significant peak on chromosome 5 (Chr5) where the PHT1;1 / 2 / 3 genes reside, suggesting a strong correlation between the regulation of Pi-uptake activity and PHT1 protein abundance. Genes encoding transcription factors, kinases, and a metalloprotease associated with both traits were also identified. Conditional GWAS followed by statistical analysis of genotype-dependent expression of PHT1;1 and transcription activity assays revealed an epistatic interaction between PHT1;1 and MYB DOMAIN PROTEIN 52 ( MYB52 ) on Chr1. Analyses of F1 hybrids generated by crossing two subgroups of natural accessions carrying specific SNPs associated with PHT1;1 and MYB52 further revealed the strong effects of potential variants on PHT1;1 expression and Pi uptake activity. Notably, the soil P contents in A. thaliana habitats were found to coincide with PHT1;1 haplotype, underscoring how fine-tuning of the activity of P acquisition by natural variants allows plants to adapt to their environments. This study sheds light on the complex regulation of P acquisition and offers a framework to systematically assess the effectiveness of GWAS approaches in the study of quantitative traits. One sentence summary Stepwise GWAS analyses reveal insights into the genetic basis in regulating phosphorus acquisition and associations between the phosphate transporter PHT1;1 haplotype and Arabidopsis habitats." @default.
- W4210361229 created "2022-02-08" @default.
- W4210361229 creator A5002345502 @default.
- W4210361229 creator A5012737894 @default.
- W4210361229 creator A5039491453 @default.
- W4210361229 creator A5063373528 @default.
- W4210361229 creator A5068932446 @default.
- W4210361229 creator A5070915167 @default.
- W4210361229 creator A5089608139 @default.
- W4210361229 date "2022-01-06" @default.
- W4210361229 modified "2023-09-27" @default.
- W4210361229 title "Phosphate transporter PHT1;1 as a key determinant of phosphorus acquisition in <i>Arabidopsis</i> natural accessions" @default.
- W4210361229 cites W1592508634 @default.
- W4210361229 cites W1975604271 @default.
- W4210361229 cites W1977708739 @default.
- W4210361229 cites W1987369873 @default.
- W4210361229 cites W2002632259 @default.
- W4210361229 cites W2016216895 @default.
- W4210361229 cites W2019734507 @default.
- W4210361229 cites W2024058212 @default.
- W4210361229 cites W2027241327 @default.
- W4210361229 cites W2030444684 @default.
- W4210361229 cites W2034376215 @default.
- W4210361229 cites W2039959586 @default.
- W4210361229 cites W2040532839 @default.
- W4210361229 cites W2042609640 @default.
- W4210361229 cites W2046269765 @default.
- W4210361229 cites W2058554931 @default.
- W4210361229 cites W2062352708 @default.
- W4210361229 cites W2062507088 @default.
- W4210361229 cites W2064496976 @default.
- W4210361229 cites W2073579158 @default.
- W4210361229 cites W2078575541 @default.
- W4210361229 cites W2081082155 @default.
- W4210361229 cites W2082695702 @default.
- W4210361229 cites W2085767084 @default.
- W4210361229 cites W2089162936 @default.
- W4210361229 cites W2090713087 @default.
- W4210361229 cites W2092806862 @default.
- W4210361229 cites W2099267861 @default.
- W4210361229 cites W2101612246 @default.
- W4210361229 cites W2103975152 @default.
- W4210361229 cites W2109633310 @default.
- W4210361229 cites W2110035718 @default.
- W4210361229 cites W2111145333 @default.
- W4210361229 cites W2114740843 @default.
- W4210361229 cites W2116122104 @default.
- W4210361229 cites W2120396983 @default.
- W4210361229 cites W2121220543 @default.
- W4210361229 cites W2121752230 @default.
- W4210361229 cites W2124516931 @default.
- W4210361229 cites W2127253105 @default.
- W4210361229 cites W2127684760 @default.
- W4210361229 cites W2135996121 @default.
- W4210361229 cites W2136053273 @default.
- W4210361229 cites W2137797806 @default.
- W4210361229 cites W2142182600 @default.
- W4210361229 cites W2145151399 @default.
- W4210361229 cites W2147326988 @default.
- W4210361229 cites W2152885121 @default.
- W4210361229 cites W2157743364 @default.
- W4210361229 cites W2159283576 @default.
- W4210361229 cites W2163843948 @default.
- W4210361229 cites W2165695296 @default.
- W4210361229 cites W2166043101 @default.
- W4210361229 cites W2167959669 @default.
- W4210361229 cites W2171091820 @default.
- W4210361229 cites W2172532093 @default.
- W4210361229 cites W2189756678 @default.
- W4210361229 cites W2227572122 @default.
- W4210361229 cites W2332091468 @default.
- W4210361229 cites W2397301551 @default.
- W4210361229 cites W2419574648 @default.
- W4210361229 cites W2551637450 @default.
- W4210361229 cites W2605533783 @default.
- W4210361229 cites W2790556376 @default.
- W4210361229 cites W2791518348 @default.
- W4210361229 cites W2792335017 @default.
- W4210361229 cites W2901153627 @default.
- W4210361229 cites W2901249214 @default.
- W4210361229 cites W2903331327 @default.
- W4210361229 cites W2974562664 @default.
- W4210361229 cites W2987896002 @default.
- W4210361229 cites W2999762814 @default.
- W4210361229 cites W3087256791 @default.
- W4210361229 cites W3201643463 @default.
- W4210361229 cites W4250635047 @default.
- W4210361229 cites W4251086924 @default.
- W4210361229 doi "https://doi.org/10.1101/2022.01.05.475091" @default.
- W4210361229 hasPublicationYear "2022" @default.
- W4210361229 type Work @default.
- W4210361229 citedByCount "0" @default.
- W4210361229 crossrefType "posted-content" @default.
- W4210361229 hasAuthorship W4210361229A5002345502 @default.
- W4210361229 hasAuthorship W4210361229A5012737894 @default.
- W4210361229 hasAuthorship W4210361229A5039491453 @default.
- W4210361229 hasAuthorship W4210361229A5063373528 @default.
- W4210361229 hasAuthorship W4210361229A5068932446 @default.
- W4210361229 hasAuthorship W4210361229A5070915167 @default.
- W4210361229 hasAuthorship W4210361229A5089608139 @default.