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- W4210361690 abstract "In recent years, tobacco smoking is a risk factor for a series of diseases, including cardiovascular diseases, cerebrovascular diseases, and cancers. Nicotine, the primary component of tobacco smoke, is mainly transformed to its active metabolite cotinine, which is often used as a biomarker for tobacco exposure for its higher blood concentration and longer residence time than nicotine. Various analytical methods have been developed for the determination of nicotine and cotinine in biological matrices. This article reviewed the HPLC-MS based methods for nicotine and/or cotinine analysis in various biological matrices. The sample preparation, mass and chromatographic conditions, and method validation results of these methods have been summarized and analyzed. The sample was mainly pretreated by protein precipitation and/or extraction. Separation was achieved using methanol and/or acetonitrile:water (with or without ammonium acetate) on C18 columns and acetonitrile:water (with formic acid, ammonium acetate/formate) on HILIC columns. Nicotine-d3, nicotine-d4, and cotinine-d3 were commonly used internal standards (ISs). Other non-deuterated ISs such as ritonavir, N-ethylnorcotinine, and milrinone were also used. For both nicotine and cotinine, the calibration range was 0.005-35,000 ng/mL, the matrix effect was 75.96-126.8%, and the recovery was 53-124.5%. The two analytes were stable at room temperature for 1-10 days, at -80°C for up to 6 months, and after three to six freeze-thaw cycles. Comedications did not affect nicotine and cotinine analyses." @default.
- W4210361690 created "2022-02-08" @default.
- W4210361690 creator A5007220899 @default.
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- W4210361690 creator A5088064629 @default.
- W4210361690 date "2022-03-11" @default.
- W4210361690 modified "2023-09-26" @default.
- W4210361690 title "Review of HPLC–MS methods for the analysis of nicotine and its active metabolite cotinine in various biological matrices" @default.
- W4210361690 cites W1471767273 @default.
- W4210361690 cites W1480909242 @default.
- W4210361690 cites W1965253586 @default.
- W4210361690 cites W1966593979 @default.
- W4210361690 cites W1969940333 @default.
- W4210361690 cites W1978872389 @default.
- W4210361690 cites W1979035182 @default.
- W4210361690 cites W1988046428 @default.
- W4210361690 cites W1988146345 @default.
- W4210361690 cites W1989324155 @default.
- W4210361690 cites W1995402453 @default.
- W4210361690 cites W1998977091 @default.
- W4210361690 cites W2002414446 @default.
- W4210361690 cites W2009098675 @default.
- W4210361690 cites W2015065608 @default.
- W4210361690 cites W2017703226 @default.
- W4210361690 cites W2020969670 @default.
- W4210361690 cites W2030471578 @default.
- W4210361690 cites W2033053358 @default.
- W4210361690 cites W2045399580 @default.
- W4210361690 cites W2047196774 @default.
- W4210361690 cites W2048523217 @default.
- W4210361690 cites W2053876848 @default.
- W4210361690 cites W2053984976 @default.
- W4210361690 cites W2059906688 @default.
- W4210361690 cites W2059934851 @default.
- W4210361690 cites W2060450637 @default.
- W4210361690 cites W2062955548 @default.
- W4210361690 cites W2063302121 @default.
- W4210361690 cites W2068208984 @default.
- W4210361690 cites W2068963836 @default.
- W4210361690 cites W2075104260 @default.
- W4210361690 cites W2075582108 @default.
- W4210361690 cites W2075917818 @default.
- W4210361690 cites W2084712153 @default.
- W4210361690 cites W2090830168 @default.
- W4210361690 cites W2090898813 @default.
- W4210361690 cites W2094580343 @default.
- W4210361690 cites W2095297630 @default.
- W4210361690 cites W2097496898 @default.
- W4210361690 cites W2098238018 @default.
- W4210361690 cites W2105865249 @default.
- W4210361690 cites W2107897538 @default.
- W4210361690 cites W2110594836 @default.
- W4210361690 cites W2111771576 @default.
- W4210361690 cites W2115312169 @default.
- W4210361690 cites W2116438644 @default.
- W4210361690 cites W2125623350 @default.
- W4210361690 cites W2125775339 @default.
- W4210361690 cites W2138051935 @default.
- W4210361690 cites W2139154576 @default.
- W4210361690 cites W2147886123 @default.
- W4210361690 cites W2155195863 @default.
- W4210361690 cites W2270770968 @default.
- W4210361690 cites W2276994481 @default.
- W4210361690 cites W2304689412 @default.
- W4210361690 cites W2322901610 @default.
- W4210361690 cites W2395700795 @default.
- W4210361690 cites W2418080515 @default.
- W4210361690 cites W2460116814 @default.
- W4210361690 cites W2565757299 @default.
- W4210361690 cites W2586560270 @default.
- W4210361690 cites W2593840983 @default.
- W4210361690 cites W2734780902 @default.
- W4210361690 cites W2736930373 @default.
- W4210361690 cites W2763841835 @default.
- W4210361690 cites W2769597312 @default.
- W4210361690 cites W2793335729 @default.
- W4210361690 cites W2794438901 @default.
- W4210361690 cites W2800561631 @default.
- W4210361690 cites W2886833440 @default.
- W4210361690 cites W2902072663 @default.
- W4210361690 cites W2904472832 @default.
- W4210361690 cites W2910435153 @default.
- W4210361690 cites W2914963133 @default.
- W4210361690 cites W2955751746 @default.
- W4210361690 cites W2990802519 @default.
- W4210361690 cites W3016202222 @default.
- W4210361690 cites W3030799374 @default.
- W4210361690 cites W3048504823 @default.
- W4210361690 cites W3080645008 @default.
- W4210361690 cites W3107432940 @default.
- W4210361690 cites W3111755615 @default.
- W4210361690 doi "https://doi.org/10.1002/bmc.5351" @default.
- W4210361690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35106788" @default.
- W4210361690 hasPublicationYear "2022" @default.
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