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• W4210361726 abstract "<h2>Abstract</h2><h3>Background</h3> : Hsa_circ_0072088 (circ_0072088) is a novel and informative circular RNA in several human cancers, including breast carcinoma (BRCA). Herewith, we aimed at investigating the role and mechanism of circ_0072088 in BRCA cells. <h3>Methods</h3> : Expression of circ_0072088, microRNA (miR)-1236-3p, ribonucleotide reductase subunit M2 (RRM2), and epithelial-to-mesenchymal transition (EMT)-related markers E-cadherin, N-cadherin and Vimentin was detected by quantitative PCR and/or western blotting. Cell proliferation was measured by assays using MTS, EdU, colony formation, immunohistochemistry and nude mice tumorigenicity. Migration/invasion and angiogenesis were determined by scratch wound assay, transwell assay, and Capillary-like tube formation assay. Intermolecular interdependence was determined by bioinformatics algorithms, dual-luciferase reporter assay, RNA pull-down assay and Pearson's correlation coefficient analysis. <h3>Results</h3> : Circ_0072088 was upregulated in BRCA patients' tumors, and its high expression was associated with clinical metastasis and unfavorable disease-free survival. Interfering circ_0072088 could weaken cell viability, colony formation, EdU incorporation, and tumor growth of BRCA cells; moreover, circ_0072088 interference suppressed wound healing, migration/invasion and EMT process of BRCA cells, and tube formation of endothelial cells. Strikingly, either miR-1236-3p inhibitor or RRM2 overexpression could significantly abate <i>in vitro</i> roles of circ_0072088 blockage. Allied with that, circ_0072088 was a sponge of miR-1236-3p in regulating expression of miR-1236-3p-specific RRM2. <h3>Conclusion</h3> : Inhibiting circ_0072088 might treat BRCA via miR-1236-3p/RRM2 axis, suggesting circPHKA2 as a novel molecular inhibitor of RRM2, a Food and Drug Administration (FDA)-approved drug target." @default.
• W4210361726 created "2022-02-08" @default.
• W4210361726 creator A5020833983 @default.
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• W4210361726 date "2022-02-01" @default.
• W4210361726 modified "2023-09-29" @default.
• W4210361726 title "Exhausting hsa_circ_0072088 restrains proliferation, motility and angiogenesis of breast carcinoma cells through regulating miR-1236-3p and RRM2 in a ceRNA pathway" @default.
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• W4210361726 doi "https://doi.org/10.1016/j.clbc.2022.02.003" @default.
• W4210361726 hasPublicationYear "2022" @default.
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