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- W4210362291 abstract "Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology, it is still largely unclear whether virus-specific T cells are sufficient for host protection. Here, we found that in a previously characterized cohort of convalescent subjects, one individual, though lacking detectable anti-viral neutralizing IgG antibodies, showed virus-specific T cell responses, both in CD4 + and CD8 + T cells. SARS-CoV-2-specific T cells in this and other individuals are maintained for up to 10 months. This study thus further supports a critical role of T cells in host defense against SARS-CoV-2, offering new insights into the design and evaluation of COVID-19 vaccines." @default.
- W4210362291 created "2022-02-08" @default.
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- W4210362291 date "2022-01-28" @default.
- W4210362291 modified "2023-10-14" @default.
- W4210362291 title " Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual" @default.
- W4210362291 doi "https://doi.org/10.1051/nso/2021003" @default.
- W4210362291 hasPublicationYear "2022" @default.
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