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• W4210362665 startingPage "43" @default.
• W4210362665 abstract "Cancer represents a leading cause of death worldwide. Hence, a better understanding of the molecular mechanisms causing and propelling the disease is of utmost importance. Several cancer entities are associated with altered K+ channel expression which is frequently decisive for malignancy and disease outcome. The impact of such oncogenic K+ channels on cell patho-/physiology and homeostasis and their roles in different subcellular compartments is, however, far from being understood. A refined method to simultaneously investigate metabolic and ionic signaling events on the level of individual cells and their organelles represent genetically encoded fluorescent biosensors, that allow a high-resolution investigation of compartmentalized metabolite or ion dynamics in a non-invasive manner. This feature of these probes makes them versatile tools to visualize and understand subcellular consequences of aberrant K+ channel expression and activity in K+ channel related cancer research." @default.
• W4210362665 created "2022-02-08" @default.
• W4210362665 creator A5008529621 @default.
• W4210362665 creator A5031003334 @default.
• W4210362665 creator A5077422700 @default.
• W4210362665 creator A5081662652 @default.
• W4210362665 date "2022-03-01" @default.
• W4210362665 modified "2023-10-17" @default.
• W4210362665 title "Assessing K+ ions and K+ channel functions in cancer cell metabolism using fluorescent biosensors" @default.
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