Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210363020> ?p ?o ?g. }
- W4210363020 endingPage "1050" @default.
- W4210363020 startingPage "1031" @default.
- W4210363020 abstract "Devaluation protocols reveal that Tourette patients show an increased propensity to habitual behaviors as they continue to respond to devalued outcomes in a cognitive stimulus-response-outcome association task. We use a neuro-computational model of hierarchically organized cortico-basal ganglia-thalamo-cortical loops to shed more light on habit formation and its alteration in Tourette patients. In our model, habitual behavior emerges from cortico-thalamic shortcut connections, where enhanced habit formation can be linked to faster plasticity in the shortcut or to a stronger feedback from the shortcut to the basal ganglia. We explore two major hypotheses of Tourette pathophysiology-local striatal disinhibition and increased dopaminergic modulation of striatal medium spiny neurons-as causes for altered shortcut activation. Both model changes altered shortcut functioning and resulted in higher rates of responses towards devalued outcomes, similar to what is observed in Tourette patients. We recommend future experimental neuroscientific studies to locate shortcuts between cortico-basal ganglia-thalamo-cortical loops in the human brain and study their potential role in health and disease." @default.
- W4210363020 created "2022-02-08" @default.
- W4210363020 creator A5016814228 @default.
- W4210363020 creator A5045377215 @default.
- W4210363020 creator A5061910857 @default.
- W4210363020 creator A5079801729 @default.
- W4210363020 date "2022-02-03" @default.
- W4210363020 modified "2023-09-26" @default.
- W4210363020 title "Enhanced habit formation in Tourette patients explained by shortcut modulation in a hierarchical cortico-basal ganglia model" @default.
- W4210363020 cites W127031644 @default.
- W4210363020 cites W1598466430 @default.
- W4210363020 cites W1674052906 @default.
- W4210363020 cites W1882556075 @default.
- W4210363020 cites W1911169438 @default.
- W4210363020 cites W1965970654 @default.
- W4210363020 cites W1967237555 @default.
- W4210363020 cites W1971999279 @default.
- W4210363020 cites W197750504 @default.
- W4210363020 cites W1981739486 @default.
- W4210363020 cites W1982522250 @default.
- W4210363020 cites W1985367358 @default.
- W4210363020 cites W1986546876 @default.
- W4210363020 cites W1993130087 @default.
- W4210363020 cites W1993621549 @default.
- W4210363020 cites W1998618539 @default.
- W4210363020 cites W2004011965 @default.
- W4210363020 cites W2007524113 @default.
- W4210363020 cites W2008005549 @default.
- W4210363020 cites W2008565771 @default.
- W4210363020 cites W2011102093 @default.
- W4210363020 cites W2011897114 @default.
- W4210363020 cites W2012483271 @default.
- W4210363020 cites W2016033342 @default.
- W4210363020 cites W2016492231 @default.
- W4210363020 cites W2020361904 @default.
- W4210363020 cites W2021782736 @default.
- W4210363020 cites W2026183293 @default.
- W4210363020 cites W2031170958 @default.
- W4210363020 cites W2052329772 @default.
- W4210363020 cites W2052677739 @default.
- W4210363020 cites W2053868794 @default.
- W4210363020 cites W2054140453 @default.
- W4210363020 cites W2056061278 @default.
- W4210363020 cites W2060469305 @default.
- W4210363020 cites W2060588252 @default.
- W4210363020 cites W2061304498 @default.
- W4210363020 cites W2065509982 @default.
- W4210363020 cites W2066309287 @default.
- W4210363020 cites W2068550370 @default.
- W4210363020 cites W2070895732 @default.
- W4210363020 cites W2076635082 @default.
- W4210363020 cites W2076792446 @default.
- W4210363020 cites W2077579927 @default.
- W4210363020 cites W2085553767 @default.
- W4210363020 cites W2086305881 @default.
- W4210363020 cites W2089277503 @default.
- W4210363020 cites W2099652807 @default.
- W4210363020 cites W2103768739 @default.
- W4210363020 cites W2105892294 @default.
- W4210363020 cites W2112479070 @default.
- W4210363020 cites W2114770633 @default.
- W4210363020 cites W2115414869 @default.
- W4210363020 cites W2116441431 @default.
- W4210363020 cites W2118830830 @default.
- W4210363020 cites W2119102767 @default.
- W4210363020 cites W2120520226 @default.
- W4210363020 cites W2123053862 @default.
- W4210363020 cites W2126349398 @default.
- W4210363020 cites W2127120806 @default.
- W4210363020 cites W2128238934 @default.
- W4210363020 cites W2133191097 @default.
- W4210363020 cites W2140270073 @default.
- W4210363020 cites W2140983215 @default.
- W4210363020 cites W2141977873 @default.
- W4210363020 cites W2142455573 @default.
- W4210363020 cites W2143988681 @default.
- W4210363020 cites W2146676986 @default.
- W4210363020 cites W2147320841 @default.
- W4210363020 cites W2149936635 @default.
- W4210363020 cites W2150139344 @default.
- W4210363020 cites W2154878037 @default.
- W4210363020 cites W2155866246 @default.
- W4210363020 cites W2156315378 @default.
- W4210363020 cites W2164237857 @default.
- W4210363020 cites W2165673024 @default.
- W4210363020 cites W2167021628 @default.
- W4210363020 cites W2167317757 @default.
- W4210363020 cites W2168447210 @default.
- W4210363020 cites W2172007174 @default.
- W4210363020 cites W2274382726 @default.
- W4210363020 cites W2292207655 @default.
- W4210363020 cites W2303881969 @default.
- W4210363020 cites W2327313909 @default.
- W4210363020 cites W2438923106 @default.
- W4210363020 cites W2592388858 @default.
- W4210363020 cites W2600179491 @default.
- W4210363020 cites W2622443338 @default.
- W4210363020 cites W2748034252 @default.