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- W4210363429 endingPage "701" @default.
- W4210363429 startingPage "701" @default.
- W4210363429 abstract "Radiation therapy is an important part of the standard of care treatment of brain tumors. However, the efficacy of radiation therapy is limited by the radioresistance of tumor cells, a phenomenon held responsible for the dismal prognosis of the most aggressive brain tumor types. A promising approach to radiosensitization of tumors is the inhibition of cell cycle checkpoint control responsible for cell cycle progression and the maintenance of genomic integrity. Inhibition of the kinases involved in these control mechanisms can abolish cell cycle checkpoints and DNA damage repair and thus increase the sensitivity of tumor cells to radiation and chemotherapy. Here, we discuss preclinical progress in molecular targeting of ATM, ATR, CHK1, CHK2, and WEE1, checkpoint kinases in the treatment of brain tumors, and review current clinical phase I-II trials." @default.
- W4210363429 created "2022-02-08" @default.
- W4210363429 creator A5005095447 @default.
- W4210363429 creator A5028318020 @default.
- W4210363429 creator A5031894590 @default.
- W4210363429 creator A5084314339 @default.
- W4210363429 date "2022-01-29" @default.
- W4210363429 modified "2023-09-25" @default.
- W4210363429 title "Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells" @default.
- W4210363429 cites W1508824749 @default.
- W4210363429 cites W1554869996 @default.
- W4210363429 cites W159711244 @default.
- W4210363429 cites W1677659983 @default.
- W4210363429 cites W1771966825 @default.
- W4210363429 cites W1963874300 @default.
- W4210363429 cites W1965239527 @default.
- W4210363429 cites W1965905617 @default.
- W4210363429 cites W1966886904 @default.
- W4210363429 cites W1967369929 @default.
- W4210363429 cites W1970924670 @default.
- W4210363429 cites W1982603542 @default.
- W4210363429 cites W1984266465 @default.
- W4210363429 cites W1985798182 @default.
- W4210363429 cites W1991199800 @default.
- W4210363429 cites W2008887283 @default.
- W4210363429 cites W2016492849 @default.
- W4210363429 cites W2018458310 @default.
- W4210363429 cites W2020261953 @default.
- W4210363429 cites W2027825753 @default.
- W4210363429 cites W2030017878 @default.
- W4210363429 cites W2031683541 @default.
- W4210363429 cites W2039373918 @default.
- W4210363429 cites W2039442869 @default.
- W4210363429 cites W2044770423 @default.
- W4210363429 cites W2045694872 @default.
- W4210363429 cites W2050128145 @default.
- W4210363429 cites W2050565506 @default.
- W4210363429 cites W2059773837 @default.
- W4210363429 cites W2060551076 @default.
- W4210363429 cites W2063579723 @default.
- W4210363429 cites W2065015030 @default.
- W4210363429 cites W2065422258 @default.
- W4210363429 cites W2073483289 @default.
- W4210363429 cites W2082084551 @default.
- W4210363429 cites W2083225541 @default.
- W4210363429 cites W2092735258 @default.
- W4210363429 cites W2093176896 @default.
- W4210363429 cites W2093442957 @default.
- W4210363429 cites W2094316812 @default.
- W4210363429 cites W2096226098 @default.
- W4210363429 cites W2096287682 @default.
- W4210363429 cites W2100078246 @default.
- W4210363429 cites W2102794619 @default.
- W4210363429 cites W2103453025 @default.
- W4210363429 cites W2106925712 @default.
- W4210363429 cites W2108574760 @default.
- W4210363429 cites W2113942802 @default.
- W4210363429 cites W2117692326 @default.
- W4210363429 cites W2120709000 @default.
- W4210363429 cites W2126309017 @default.
- W4210363429 cites W2133436567 @default.
- W4210363429 cites W2134457209 @default.
- W4210363429 cites W2134647795 @default.
- W4210363429 cites W2137960650 @default.
- W4210363429 cites W2138348020 @default.
- W4210363429 cites W2140656629 @default.
- W4210363429 cites W2145747268 @default.
- W4210363429 cites W2146498297 @default.
- W4210363429 cites W2148636166 @default.
- W4210363429 cites W2148977460 @default.
- W4210363429 cites W2150106850 @default.
- W4210363429 cites W2151293938 @default.
- W4210363429 cites W2151808807 @default.
- W4210363429 cites W2152387543 @default.
- W4210363429 cites W2155957543 @default.
- W4210363429 cites W2158402289 @default.
- W4210363429 cites W2158681922 @default.
- W4210363429 cites W2161289668 @default.
- W4210363429 cites W2161394680 @default.
- W4210363429 cites W2165382252 @default.
- W4210363429 cites W2165400661 @default.
- W4210363429 cites W2165871546 @default.
- W4210363429 cites W2167196101 @default.
- W4210363429 cites W2307481467 @default.
- W4210363429 cites W2341448642 @default.
- W4210363429 cites W2470708296 @default.
- W4210363429 cites W2511137141 @default.
- W4210363429 cites W2554298913 @default.
- W4210363429 cites W2610403529 @default.
- W4210363429 cites W2619402113 @default.
- W4210363429 cites W2625452721 @default.
- W4210363429 cites W2733728111 @default.
- W4210363429 cites W2743410506 @default.
- W4210363429 cites W2756931306 @default.
- W4210363429 cites W2760019720 @default.
- W4210363429 cites W2770128744 @default.
- W4210363429 cites W2787120596 @default.
- W4210363429 cites W2789347908 @default.