Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210363762> ?p ?o ?g. }
- W4210363762 endingPage "2200389" @default.
- W4210363762 startingPage "2200389" @default.
- W4210363762 abstract "Both tumor-associated macrophages (TAMs) and hypoxia condition severely restrict the antitumor potency during cancer immunotherapy. It is essential to overcome the two issues for improving therapeutic efficacy. In this study, a hollow mesoporous Prussian blue (HMPB) nanosystem with mannose decoration and hydroxychloroquine (HCQ) adsorption is built, to form Man-HMPB/HCQ. It can facilitate cellular internalization via mannose-receptor mediated endocytosis and induce TAM polarization via iron ion/HCQ release with HMPB degradation. The hybrid macrophage and thylakoid (TK) membrane is camouflaged on the Man-HMPB/HCQ surface, denoted as TK-M@Man-HMPB/HCQ, to reduce in vivo reticuloendothelial system uptake, enhance tumor accumulation, and mitigate hypoxia. The in vivo results indicate that TK-M@Man-HMPB/HCQ notably inhibits tumor growth, induces TAM polarization, facilitates cytotoxic T lymphocytes infiltration, and alleviates hypoxia microenvironment. The rational design may provide a new pathway to modulate the tumor microenvironment for promoting cancer immunotherapy effects." @default.
- W4210363762 created "2022-02-08" @default.
- W4210363762 creator A5018249388 @default.
- W4210363762 creator A5022619874 @default.
- W4210363762 creator A5047856010 @default.
- W4210363762 creator A5063117062 @default.
- W4210363762 creator A5067715314 @default.
- W4210363762 date "2022-02-21" @default.
- W4210363762 modified "2023-09-23" @default.
- W4210363762 title "Hybrid‐Membrane‐Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor‐Associated Macrophages Polarization and Hypoxia Relief" @default.
- W4210363762 cites W1970180992 @default.
- W4210363762 cites W1971620413 @default.
- W4210363762 cites W2001717792 @default.
- W4210363762 cites W2003505989 @default.
- W4210363762 cites W2190141802 @default.
- W4210363762 cites W2427645657 @default.
- W4210363762 cites W2528843175 @default.
- W4210363762 cites W2588049964 @default.
- W4210363762 cites W2609512644 @default.
- W4210363762 cites W2619530121 @default.
- W4210363762 cites W2735577231 @default.
- W4210363762 cites W2783019104 @default.
- W4210363762 cites W2792745666 @default.
- W4210363762 cites W2793195158 @default.
- W4210363762 cites W2804447831 @default.
- W4210363762 cites W2804669050 @default.
- W4210363762 cites W2849172012 @default.
- W4210363762 cites W2885552659 @default.
- W4210363762 cites W2902979010 @default.
- W4210363762 cites W2921090220 @default.
- W4210363762 cites W2921107404 @default.
- W4210363762 cites W2923186456 @default.
- W4210363762 cites W2934131312 @default.
- W4210363762 cites W2963700080 @default.
- W4210363762 cites W2975150216 @default.
- W4210363762 cites W2976182269 @default.
- W4210363762 cites W2981897125 @default.
- W4210363762 cites W2982245165 @default.
- W4210363762 cites W3009313319 @default.
- W4210363762 cites W3011328293 @default.
- W4210363762 cites W3034128589 @default.
- W4210363762 cites W3039442005 @default.
- W4210363762 cites W3047868968 @default.
- W4210363762 cites W3050950703 @default.
- W4210363762 cites W3082328907 @default.
- W4210363762 cites W3092269784 @default.
- W4210363762 cites W3094037746 @default.
- W4210363762 cites W3121844112 @default.
- W4210363762 cites W3135626173 @default.
- W4210363762 cites W3136819448 @default.
- W4210363762 cites W3177278212 @default.
- W4210363762 doi "https://doi.org/10.1002/adma.202200389" @default.
- W4210363762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35103352" @default.
- W4210363762 hasPublicationYear "2022" @default.
- W4210363762 type Work @default.
- W4210363762 citedByCount "40" @default.
- W4210363762 countsByYear W42103637622022 @default.
- W4210363762 countsByYear W42103637622023 @default.
- W4210363762 crossrefType "journal-article" @default.
- W4210363762 hasAuthorship W4210363762A5018249388 @default.
- W4210363762 hasAuthorship W4210363762A5022619874 @default.
- W4210363762 hasAuthorship W4210363762A5047856010 @default.
- W4210363762 hasAuthorship W4210363762A5063117062 @default.
- W4210363762 hasAuthorship W4210363762A5067715314 @default.
- W4210363762 hasConcept C126322002 @default.
- W4210363762 hasConcept C147789679 @default.
- W4210363762 hasConcept C150903083 @default.
- W4210363762 hasConcept C17525397 @default.
- W4210363762 hasConcept C185592680 @default.
- W4210363762 hasConcept C192562407 @default.
- W4210363762 hasConcept C202751555 @default.
- W4210363762 hasConcept C203014093 @default.
- W4210363762 hasConcept C207001950 @default.
- W4210363762 hasConcept C2776107976 @default.
- W4210363762 hasConcept C2776205754 @default.
- W4210363762 hasConcept C2777701055 @default.
- W4210363762 hasConcept C2779064266 @default.
- W4210363762 hasConcept C2779081379 @default.
- W4210363762 hasConcept C2779244956 @default.
- W4210363762 hasConcept C2780674031 @default.
- W4210363762 hasConcept C3020616263 @default.
- W4210363762 hasConcept C502942594 @default.
- W4210363762 hasConcept C509974204 @default.
- W4210363762 hasConcept C52859227 @default.
- W4210363762 hasConcept C55493867 @default.
- W4210363762 hasConcept C71924100 @default.
- W4210363762 hasConcept C86803240 @default.
- W4210363762 hasConcept C8891405 @default.
- W4210363762 hasConcept C98274493 @default.
- W4210363762 hasConceptScore W4210363762C126322002 @default.
- W4210363762 hasConceptScore W4210363762C147789679 @default.
- W4210363762 hasConceptScore W4210363762C150903083 @default.
- W4210363762 hasConceptScore W4210363762C17525397 @default.
- W4210363762 hasConceptScore W4210363762C185592680 @default.
- W4210363762 hasConceptScore W4210363762C192562407 @default.
- W4210363762 hasConceptScore W4210363762C202751555 @default.
- W4210363762 hasConceptScore W4210363762C203014093 @default.
- W4210363762 hasConceptScore W4210363762C207001950 @default.