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• W4210363810 abstract "Maintenance of germline genomic integrity is critical for the survival of animal species. Consequently, many cellular and molecular processes have evolved to ensure genetic stability during the production of gametes. Here, we describe the discovery, characterization, and emerging molecular mechanisms of the protein Asterix/Gametocyte-specific factor 1 (GTSF1), an essential gametogenesis factor that is conserved from insects to humans. Beyond its broad importance for healthy germline development, Asterix/GTSF1 has more specific functions in the Piwi-interacting RNA (piRNA)-RNA interference pathway. There, it contributes to the repression of otherwise deleterious transposons, helping to ensure faithful transmission of genetic information to the next generation. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications." @default.
• W4210363810 created "2022-02-08" @default.
• W4210363810 creator A5010770621 @default.
• W4210363810 creator A5076746607 @default.
• W4210363810 date "2022-02-02" @default.
• W4210363810 modified "2023-10-01" @default.
• W4210363810 title "Developmental roles and molecular mechanisms of Asterix/GTSF1" @default.
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• W4210363810 doi "https://doi.org/10.1002/wrna.1716" @default.
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