FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210365165> ?p ?o ?g. }

• W4210365165 endingPage "1472" @default.
• W4210365165 startingPage "1465" @default.
• W4210365165 abstract "Aberrant histone acetylation is increasingly thought to play important roles in the pathogenesis of autoimmune diseases. However, there are very few data on histone acetylation in primary Sjögren's syndrome (pSS). We aimed to investigate whether there was abnormal histones acetylation in patients with pSS.We investigated the expressions of histone acetyltransferase (HAT) genes (p300, CREBBP and PCAF) by real-time PCR in the peripheral blood mononuclear cells (PBMCs) of pSS patients. HAT activity and histone H3/H4 acetylation activity were measured by activity kit, and histone H3/H4 acetylation was verified by Western blot (WB). Spearman test was utilized to analyze the association between HAT activity levels and clinical parameters of pSS patients.The mRNA expressions of p300, CREBBP and PCAF in PBMCs from pSS patients were decreased in comparison with healthy controls (P < 0.05). HAT activity and histone H3/H4 acetylation were reduced in PBMCs from pSS patients (P < 0.05). We found that HAT activity was negatively correlated with CRP (P = 0.040) and TNF-α (P = 0.012), and was positively correlated with C4 (P = 0.041).Histone hypoacetylation is observed in patients with pSS and is involved in the pathogenesis of pSS.• The mRNA expressions of p300, CREBBP and PCAF in PBMCs from pSS patients were decreased in comparison with HCs. • HAT activity and histone H3/H4 acetylation were reduced in PBMCs from pSS patients. • HAT activity was correlated with disease characters. • We show for the first time that the histone hypoacetylation may be involved in the pathogenesis of pSS." @default.
• W4210365165 created "2022-02-08" @default.
• W4210365165 creator A5001876116 @default.
• W4210365165 creator A5002778560 @default.
• W4210365165 creator A5018863416 @default.
• W4210365165 creator A5026984704 @default.
• W4210365165 creator A5028778683 @default.
• W4210365165 creator A5034279254 @default.
• W4210365165 creator A5075203715 @default.
• W4210365165 creator A5089846721 @default.
• W4210365165 date "2022-01-29" @default.
• W4210365165 modified "2023-10-16" @default.
• W4210365165 title "Abnormal Histones Acetylation in Patients with Primary Sjögren's Syndrome" @default.
• W4210365165 cites W1520386242 @default.
• W4210365165 cites W1645847737 @default.
• W4210365165 cites W1687968277 @default.
• W4210365165 cites W1981022538 @default.
• W4210365165 cites W2000889606 @default.
• W4210365165 cites W2002191009 @default.
• W4210365165 cites W2007335181 @default.
• W4210365165 cites W2016177620 @default.
• W4210365165 cites W2036565444 @default.
• W4210365165 cites W2059172839 @default.
• W4210365165 cites W2068113234 @default.
• W4210365165 cites W2078127895 @default.
• W4210365165 cites W2082685967 @default.
• W4210365165 cites W2082784195 @default.
• W4210365165 cites W2082825961 @default.
• W4210365165 cites W2093342054 @default.
• W4210365165 cites W2096081005 @default.
• W4210365165 cites W2111194763 @default.
• W4210365165 cites W2115001737 @default.
• W4210365165 cites W2128549181 @default.
• W4210365165 cites W2147272168 @default.
• W4210365165 cites W2152168497 @default.
• W4210365165 cites W2164775373 @default.
• W4210365165 cites W2206954443 @default.
• W4210365165 cites W2276751003 @default.
• W4210365165 cites W2335982655 @default.
• W4210365165 cites W2346505513 @default.
• W4210365165 cites W2418962565 @default.
• W4210365165 cites W2470107379 @default.
• W4210365165 cites W2562212325 @default.
• W4210365165 cites W2767841440 @default.
• W4210365165 cites W2792742956 @default.
• W4210365165 cites W2792811860 @default.
• W4210365165 doi "https://doi.org/10.1007/s10067-021-06036-4" @default.
• W4210365165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35091779" @default.
• W4210365165 hasPublicationYear "2022" @default.
• W4210365165 type Work @default.
• W4210365165 citedByCount "5" @default.
• W4210365165 countsByYear W42103651652023 @default.
• W4210365165 crossrefType "journal-article" @default.
• W4210365165 hasAuthorship W4210365165A5001876116 @default.
• W4210365165 hasAuthorship W4210365165A5002778560 @default.
• W4210365165 hasAuthorship W4210365165A5018863416 @default.
• W4210365165 hasAuthorship W4210365165A5026984704 @default.
• W4210365165 hasAuthorship W4210365165A5028778683 @default.
• W4210365165 hasAuthorship W4210365165A5034279254 @default.
• W4210365165 hasAuthorship W4210365165A5075203715 @default.
• W4210365165 hasAuthorship W4210365165A5089846721 @default.
• W4210365165 hasBestOaLocation W42103651652 @default.
• W4210365165 hasConcept C104317684 @default.
• W4210365165 hasConcept C107793267 @default.
• W4210365165 hasConcept C119157956 @default.
• W4210365165 hasConcept C126322002 @default.
• W4210365165 hasConcept C137061746 @default.
• W4210365165 hasConcept C153911025 @default.
• W4210365165 hasConcept C202751555 @default.
• W4210365165 hasConcept C203014093 @default.
• W4210365165 hasConcept C2778001298 @default.
• W4210365165 hasConcept C2779085176 @default.
• W4210365165 hasConcept C2780942790 @default.
• W4210365165 hasConcept C2910921701 @default.
• W4210365165 hasConcept C502942594 @default.
• W4210365165 hasConcept C54355233 @default.
• W4210365165 hasConcept C56428682 @default.
• W4210365165 hasConcept C64927066 @default.
• W4210365165 hasConcept C71924100 @default.
• W4210365165 hasConcept C86803240 @default.
• W4210365165 hasConceptScore W4210365165C104317684 @default.
• W4210365165 hasConceptScore W4210365165C107793267 @default.
• W4210365165 hasConceptScore W4210365165C119157956 @default.
• W4210365165 hasConceptScore W4210365165C126322002 @default.
• W4210365165 hasConceptScore W4210365165C137061746 @default.
• W4210365165 hasConceptScore W4210365165C153911025 @default.
• W4210365165 hasConceptScore W4210365165C202751555 @default.
• W4210365165 hasConceptScore W4210365165C203014093 @default.
• W4210365165 hasConceptScore W4210365165C2778001298 @default.
• W4210365165 hasConceptScore W4210365165C2779085176 @default.
• W4210365165 hasConceptScore W4210365165C2780942790 @default.
• W4210365165 hasConceptScore W4210365165C2910921701 @default.
• W4210365165 hasConceptScore W4210365165C502942594 @default.
• W4210365165 hasConceptScore W4210365165C54355233 @default.
• W4210365165 hasConceptScore W4210365165C56428682 @default.
• W4210365165 hasConceptScore W4210365165C64927066 @default.
• W4210365165 hasConceptScore W4210365165C71924100 @default.
• W4210365165 hasConceptScore W4210365165C86803240 @default.

• next