Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210366143> ?p ?o ?g. }
- W4210366143 endingPage "334" @default.
- W4210366143 startingPage "325" @default.
- W4210366143 abstract "Elderly patients with newly diagnosed glioblastoma (eGBM) carry a worse prognosis compared with their younger counterparts. eGBM garners special attention due to the unique challenges, including increased treatment-associated toxicity, less relative benefit from aggressive therapy, medical comorbidities, and immunosuppression. The pivotal GBM trials excluded patients > 70 years old and the optimal treatment approach remains unsettled for eGBM. In this review, we analyze the historical evidence-based data for treating eGBM and discuss the future direction for managing this vulnerable population.Treatment for eGBM continues to evolve. Therapy choice is guided by performance status and presence of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation. For eGBM with good performance status, combinatorial hypofractionated radiation therapy (hRT) and temozolomide should be recommended. For those with poor performance status, further stratification based on MGMT promoter methylation test result is recommended. Single-agent temozolomide is a viable treatment option for MGMT methylated tumors (mMGMT); in particular, those classified with receptor tyrosine kinase II methylation. hRT alone can be considered in MGMT unmethylated (uMGMT) eGBM patients. As precision oncology continues to advance, effective targeted and immunotherapy may emerge as new treatment options for eGBM. Management of elderly patients with newly diagnosed GBM carries a unique set of challenges. Progress has been made in defining the optimal therapeutic approach for these patients, but many questions remain to be answered." @default.
- W4210366143 created "2022-02-08" @default.
- W4210366143 creator A5001958837 @default.
- W4210366143 creator A5012877310 @default.
- W4210366143 creator A5050534702 @default.
- W4210366143 date "2022-02-05" @default.
- W4210366143 modified "2023-10-07" @default.
- W4210366143 title "Newly Diagnosed Glioblastoma in Elderly Patients" @default.
- W4210366143 cites W1502789305 @default.
- W4210366143 cites W1581790859 @default.
- W4210366143 cites W1958269815 @default.
- W4210366143 cites W1964025236 @default.
- W4210366143 cites W1981911197 @default.
- W4210366143 cites W1985745192 @default.
- W4210366143 cites W1992661992 @default.
- W4210366143 cites W2001660159 @default.
- W4210366143 cites W2006234544 @default.
- W4210366143 cites W2007678878 @default.
- W4210366143 cites W2009809826 @default.
- W4210366143 cites W2013816626 @default.
- W4210366143 cites W2014297744 @default.
- W4210366143 cites W2017251238 @default.
- W4210366143 cites W2027563979 @default.
- W4210366143 cites W2032342631 @default.
- W4210366143 cites W2036050012 @default.
- W4210366143 cites W2045510579 @default.
- W4210366143 cites W2053717655 @default.
- W4210366143 cites W2054553927 @default.
- W4210366143 cites W2073873308 @default.
- W4210366143 cites W2074599342 @default.
- W4210366143 cites W2083788852 @default.
- W4210366143 cites W2088404098 @default.
- W4210366143 cites W2089640963 @default.
- W4210366143 cites W2094666767 @default.
- W4210366143 cites W2096287682 @default.
- W4210366143 cites W2099199992 @default.
- W4210366143 cites W2105100844 @default.
- W4210366143 cites W2105113857 @default.
- W4210366143 cites W2105348749 @default.
- W4210366143 cites W2105528101 @default.
- W4210366143 cites W2107731988 @default.
- W4210366143 cites W2113762218 @default.
- W4210366143 cites W2116485123 @default.
- W4210366143 cites W2118331429 @default.
- W4210366143 cites W2124736921 @default.
- W4210366143 cites W2126817554 @default.
- W4210366143 cites W2132697290 @default.
- W4210366143 cites W2133611748 @default.
- W4210366143 cites W2135396269 @default.
- W4210366143 cites W2148977460 @default.
- W4210366143 cites W2154526619 @default.
- W4210366143 cites W2156330848 @default.
- W4210366143 cites W2156877668 @default.
- W4210366143 cites W2158681922 @default.
- W4210366143 cites W2162605078 @default.
- W4210366143 cites W2164753697 @default.
- W4210366143 cites W2164890947 @default.
- W4210366143 cites W2165871546 @default.
- W4210366143 cites W2166469535 @default.
- W4210366143 cites W2167923186 @default.
- W4210366143 cites W2258640840 @default.
- W4210366143 cites W2291779814 @default.
- W4210366143 cites W2303158491 @default.
- W4210366143 cites W2336854603 @default.
- W4210366143 cites W2524525752 @default.
- W4210366143 cites W2526607882 @default.
- W4210366143 cites W2564132000 @default.
- W4210366143 cites W2593604059 @default.
- W4210366143 cites W2599750069 @default.
- W4210366143 cites W2610403529 @default.
- W4210366143 cites W2610420681 @default.
- W4210366143 cites W2724967061 @default.
- W4210366143 cites W2738659978 @default.
- W4210366143 cites W2745828203 @default.
- W4210366143 cites W2768388636 @default.
- W4210366143 cites W2778283729 @default.
- W4210366143 cites W2797840381 @default.
- W4210366143 cites W2887095121 @default.
- W4210366143 cites W2887534453 @default.
- W4210366143 cites W2888793529 @default.
- W4210366143 cites W2894102714 @default.
- W4210366143 cites W2922585042 @default.
- W4210366143 cites W2922922277 @default.
- W4210366143 cites W2976169840 @default.
- W4210366143 cites W2980106975 @default.
- W4210366143 cites W3005337228 @default.
- W4210366143 cites W3006813113 @default.
- W4210366143 cites W3012937109 @default.
- W4210366143 cites W3020491131 @default.
- W4210366143 cites W3021306676 @default.
- W4210366143 cites W3021575924 @default.
- W4210366143 cites W3026551532 @default.
- W4210366143 cites W3030776299 @default.
- W4210366143 cites W3034030853 @default.
- W4210366143 cites W3034397908 @default.
- W4210366143 cites W3034695976 @default.
- W4210366143 cites W3091751890 @default.
- W4210366143 cites W3102145434 @default.