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- W4210368718 abstract "Invasive breast cancer (BC) is the most common cancer in women with a slightly increasing yearly incidence. BC immunohistochemical characterisation is a crucial tool to define the intrinsic nature of each tumour and personalise BC patients' clinical management. In this regard, the characterisation of human epidermal growth factor receptor 2 (HER2) status guides physicians to treat with therapies tailored to this membrane receptor. Standardly, a tumour solid biopsy is therefore required, which is an invasive procedure and has difficulties to provide the complete molecular picture of the tumour. To complement these standard-of-care approaches, liquid biopsy is a validated methodology to obtain circulating tumour components such as circulating tumour DNA (ctDNA) and circulating tumour cells (CTCs) from body fluids in an easy-to-perform minimal-invasive manner. However, its clinical validity in cancer is still to be demonstrated. This review focusses on the utilisation of both ctDNA and CTCs in early and metastatic HER2-positive BC tumours. We discuss recently published studies deciphering the capacity of liquid biopsy to determine the response to neoadjuvant and adjuvant therapies as well as to predict patients' outcomes." @default.
- W4210368718 created "2022-02-08" @default.
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- W4210368718 date "2022-01-24" @default.
- W4210368718 modified "2023-09-30" @default.
- W4210368718 title "Unveiling the Potential of Liquid Biopsy in HER2-Positive Breast Cancer Management" @default.
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- W4210368718 doi "https://doi.org/10.3390/cancers14030587" @default.
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- W4210368718 hasPublicationYear "2022" @default.
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