FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210369436> ?p ?o ?g. }

• W4210369436 endingPage "2204.e11" @default.
• W4210369436 startingPage "2194" @default.
• W4210369436 abstract "Lipocalins are a family of secreted adipokines that regulate cell lipid metabolism and immune responses. Although we have previously revealed that LCN2 modulates neutrophil activation in psoriasis, the other roles of LCN2 in psoriatic local inflammation have remained elusive. In this study, we found that 24p3R, the well-known specific receptor of LCN2, was highly expressed in the lesional epidermis of patients with psoriasis. Silencing 24p3R (also known as slc22a17) alleviated hyperkeratosis, inflammatory cell infiltration, and overexpression of inflammatory mediators in an imiquimod-induced psoriasis-like mouse model. In vitro, LCN2 enhanced the expression of proinflammatory factors in primary keratinocytes, such as IL-1β, IL-23, CXCL1, and CXCL10, which was paralleled by enforced cholesterol biosynthetic signaling. Importantly, taking in vivo and in vitro approaches, we discovered the SREBP2, a vital transcriptional factor in cholesterol synthesis pathway, as the critical mediator of LCN2-induced keratinocyte activation, which bound to the promoter region of NLRC4. Suppressing SREBP2 in mice attenuated NLRC4 signaling and psoriasis-like dermatitis. Taken together, this study identifies the critical role of LCN2‒SREBP2‒NLRC4 axis in the pathogenesis of psoriasis and proposes 24p3R or SREBP2 as a potential therapeutic target for psoriasis." @default.
• W4210369436 created "2022-02-08" @default.
• W4210369436 creator A5014208092 @default.
• W4210369436 creator A5023409109 @default.
• W4210369436 creator A5029874719 @default.
• W4210369436 creator A5030921116 @default.
• W4210369436 creator A5030956392 @default.
• W4210369436 creator A5043994875 @default.
• W4210369436 creator A5048915407 @default.
• W4210369436 creator A5054134534 @default.
• W4210369436 creator A5055160450 @default.
• W4210369436 creator A5055666446 @default.
• W4210369436 creator A5062602756 @default.
• W4210369436 creator A5073216396 @default.
• W4210369436 creator A5074679765 @default.
• W4210369436 creator A5089879316 @default.
• W4210369436 date "2022-08-01" @default.
• W4210369436 modified "2023-10-15" @default.
• W4210369436 title "LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis" @default.
• W4210369436 cites W1562553409 @default.
• W4210369436 cites W1939997832 @default.
• W4210369436 cites W2152863656 @default.
• W4210369436 cites W2289667985 @default.
• W4210369436 cites W2293309775 @default.
• W4210369436 cites W2346459141 @default.
• W4210369436 cites W2527347986 @default.
• W4210369436 cites W2592143606 @default.
• W4210369436 cites W2592496066 @default.
• W4210369436 cites W2783155490 @default.
• W4210369436 cites W2794383917 @default.
• W4210369436 cites W2803854938 @default.
• W4210369436 cites W2897547577 @default.
• W4210369436 cites W2916090675 @default.
• W4210369436 cites W2923520695 @default.
• W4210369436 cites W2929230966 @default.
• W4210369436 cites W2962552845 @default.
• W4210369436 cites W2975985297 @default.
• W4210369436 cites W2992534356 @default.
• W4210369436 cites W2997996943 @default.
• W4210369436 cites W3029598181 @default.
• W4210369436 cites W3034487345 @default.
• W4210369436 cites W3035770450 @default.
• W4210369436 cites W3042180132 @default.
• W4210369436 cites W3042555200 @default.
• W4210369436 cites W3043398874 @default.
• W4210369436 cites W3046296214 @default.
• W4210369436 cites W3047992616 @default.
• W4210369436 cites W3081834127 @default.
• W4210369436 cites W3097383352 @default.
• W4210369436 cites W3132811058 @default.
• W4210369436 cites W3159411730 @default.
• W4210369436 doi "https://doi.org/10.1016/j.jid.2022.01.012" @default.
• W4210369436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35120997" @default.
• W4210369436 hasPublicationYear "2022" @default.
• W4210369436 type Work @default.
• W4210369436 citedByCount "12" @default.
• W4210369436 countsByYear W42103694362022 @default.
• W4210369436 countsByYear W42103694362023 @default.
• W4210369436 crossrefType "journal-article" @default.
• W4210369436 hasAuthorship W4210369436A5014208092 @default.
• W4210369436 hasAuthorship W4210369436A5023409109 @default.
• W4210369436 hasAuthorship W4210369436A5029874719 @default.
• W4210369436 hasAuthorship W4210369436A5030921116 @default.
• W4210369436 hasAuthorship W4210369436A5030956392 @default.
• W4210369436 hasAuthorship W4210369436A5043994875 @default.
• W4210369436 hasAuthorship W4210369436A5048915407 @default.
• W4210369436 hasAuthorship W4210369436A5054134534 @default.
• W4210369436 hasAuthorship W4210369436A5055160450 @default.
• W4210369436 hasAuthorship W4210369436A5055666446 @default.
• W4210369436 hasAuthorship W4210369436A5062602756 @default.
• W4210369436 hasAuthorship W4210369436A5073216396 @default.
• W4210369436 hasAuthorship W4210369436A5074679765 @default.
• W4210369436 hasAuthorship W4210369436A5089879316 @default.
• W4210369436 hasBestOaLocation W42103694361 @default.
• W4210369436 hasConcept C118995209 @default.
• W4210369436 hasConcept C164027704 @default.
• W4210369436 hasConcept C203014093 @default.
• W4210369436 hasConcept C2776914184 @default.
• W4210369436 hasConcept C2777074287 @default.
• W4210369436 hasConcept C2777209026 @default.
• W4210369436 hasConcept C2780564577 @default.
• W4210369436 hasConcept C54355233 @default.
• W4210369436 hasConcept C81885089 @default.
• W4210369436 hasConcept C86803240 @default.
• W4210369436 hasConcept C95444343 @default.
• W4210369436 hasConceptScore W4210369436C118995209 @default.
• W4210369436 hasConceptScore W4210369436C164027704 @default.
• W4210369436 hasConceptScore W4210369436C203014093 @default.
• W4210369436 hasConceptScore W4210369436C2776914184 @default.
• W4210369436 hasConceptScore W4210369436C2777074287 @default.
• W4210369436 hasConceptScore W4210369436C2777209026 @default.
• W4210369436 hasConceptScore W4210369436C2780564577 @default.
• W4210369436 hasConceptScore W4210369436C54355233 @default.
• W4210369436 hasConceptScore W4210369436C81885089 @default.
• W4210369436 hasConceptScore W4210369436C86803240 @default.
• W4210369436 hasConceptScore W4210369436C95444343 @default.
• W4210369436 hasFunder F4320321001 @default.
• W4210369436 hasIssue "8" @default.

• next