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• W4210369530 endingPage "314" @default.
• W4210369530 startingPage "303" @default.
• W4210369530 abstract "Apurinic/apyrimidinic (AP) sites appear in DNA spontaneously and as intermediates of base excision DNA repair. AP sites are noninstructive lesions: they strongly block DNA polymerases, and if bypassed, the nature of the incorporated dNMP is mostly guided by the interactions within the polymerase-DNA active site. Many DNA polymerases follow the A-rule, preferentially incorporating dAMP opposite to natural AP sites. Methoxyamine (MX), a small molecule, efficiently reacts with the aldehyde moiety of natural AP sites, thereby preventing their cleavage by APEX1, the major human AP endonuclease. MX is currently regarded as a possible sensitizer of cancer cells toward DNA-damaging drugs. To evaluate the mutagenic potential of MX, we have studied the utilization of various dNTPs by five DNA polymerases of different families encountering MX-AP adducts in the template in comparison with the natural aldehydic AP site. The Klenow fragment of Escherichia coli DNA polymerase I strictly followed the A-rule with both natural AP and MX-adducted AP sites. Phage RB69 DNA polymerase, a close relative of human DNA polymerases δ and ε, efficiently incorporated both dAMP and dGMP. DNA polymerase β mostly incorporated dAMP and dCMP, preferring dCMP opposite to the natural AP site and dAMP opposite to the MX-AP site, while DNA polymerase λ was selective for dGMP, apparently via the primer misalignment mechanism. Finally, translesion DNA polymerase κ also followed the A-rule for MX-AP and additionally incorporated dCMP opposite to a natural AP site. Overall, the MX-AP site, despite structural differences, was similar to the natural AP site in terms of the dNMP misincorporation preference but was bypassed less efficiently by all polymerases except for Pol κ." @default.
• W4210369530 created "2022-02-08" @default.
• W4210369530 creator A5051552099 @default.
• W4210369530 creator A5086226667 @default.
• W4210369530 date "2022-01-28" @default.
• W4210369530 modified "2023-10-17" @default.
• W4210369530 title "Miscoding and DNA Polymerase Stalling by Methoxyamine-Adducted Abasic Sites" @default.
• W4210369530 cites W1483558920 @default.
• W4210369530 cites W1648266957 @default.
• W4210369530 cites W1830811929 @default.
• W4210369530 cites W1884115821 @default.
• W4210369530 cites W1969995067 @default.
• W4210369530 cites W1970080065 @default.
• W4210369530 cites W1972662363 @default.
• W4210369530 cites W1972717311 @default.
• W4210369530 cites W1973268287 @default.
• W4210369530 cites W1980494998 @default.
• W4210369530 cites W1980745500 @default.
• W4210369530 cites W1983825041 @default.
• W4210369530 cites W1985370614 @default.
• W4210369530 cites W1987610133 @default.
• W4210369530 cites W1988328659 @default.
• W4210369530 cites W1992506016 @default.
• W4210369530 cites W1994497887 @default.
• W4210369530 cites W1994567145 @default.
• W4210369530 cites W2006470414 @default.
• W4210369530 cites W2006970678 @default.
• W4210369530 cites W2009007206 @default.
• W4210369530 cites W2009168907 @default.
• W4210369530 cites W2009468812 @default.
• W4210369530 cites W2010198692 @default.
• W4210369530 cites W2013580792 @default.
• W4210369530 cites W2016794654 @default.
• W4210369530 cites W2017072041 @default.
• W4210369530 cites W2017469665 @default.
• W4210369530 cites W2018644879 @default.
• W4210369530 cites W2019983949 @default.
• W4210369530 cites W2022049642 @default.
• W4210369530 cites W2025940055 @default.
• W4210369530 cites W2026768632 @default.
• W4210369530 cites W2026830245 @default.
• W4210369530 cites W2026837912 @default.
• W4210369530 cites W2029235977 @default.
• W4210369530 cites W2034453536 @default.
• W4210369530 cites W2036011255 @default.
• W4210369530 cites W2037260139 @default.
• W4210369530 cites W2044119105 @default.
• W4210369530 cites W2044208810 @default.
• W4210369530 cites W2045393547 @default.
• W4210369530 cites W2050401392 @default.
• W4210369530 cites W2050671522 @default.
• W4210369530 cites W2052965880 @default.
• W4210369530 cites W2059828267 @default.
• W4210369530 cites W2063096081 @default.
• W4210369530 cites W2066810031 @default.
• W4210369530 cites W2068010418 @default.
• W4210369530 cites W2071361944 @default.
• W4210369530 cites W2071522201 @default.
• W4210369530 cites W2080484095 @default.
• W4210369530 cites W2081065174 @default.
• W4210369530 cites W2082561902 @default.
• W4210369530 cites W2087667357 @default.
• W4210369530 cites W2087917559 @default.
• W4210369530 cites W2098461884 @default.
• W4210369530 cites W2105293901 @default.
• W4210369530 cites W2107119563 @default.
• W4210369530 cites W2107787439 @default.
• W4210369530 cites W2110648735 @default.
• W4210369530 cites W2112282670 @default.
• W4210369530 cites W2123588904 @default.
• W4210369530 cites W2127148491 @default.
• W4210369530 cites W2127332907 @default.
• W4210369530 cites W2133093457 @default.
• W4210369530 cites W2135511433 @default.
• W4210369530 cites W2136581914 @default.
• W4210369530 cites W2136852830 @default.
• W4210369530 cites W2138263320 @default.
• W4210369530 cites W2141230078 @default.
• W4210369530 cites W2162964765 @default.
• W4210369530 cites W2164390042 @default.
• W4210369530 cites W2169350212 @default.
• W4210369530 cites W2477626371 @default.
• W4210369530 cites W2551267107 @default.
• W4210369530 cites W2610890116 @default.
• W4210369530 cites W2735962445 @default.
• W4210369530 cites W2742885817 @default.
• W4210369530 cites W29362848 @default.
• W4210369530 cites W3022184968 @default.
• W4210369530 cites W4244396048 @default.
• W4210369530 doi "https://doi.org/10.1021/acs.chemrestox.1c00359" @default.
• W4210369530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35089032" @default.
• W4210369530 hasPublicationYear "2022" @default.
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