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- W4210369931 abstract "Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding syncoilin, intermediate filament protein, SYNC, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. SYNC expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. SYNC expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of SYNC is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. SYNC may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression." @default.
- W4210369931 created "2022-02-08" @default.
- W4210369931 creator A5024900493 @default.
- W4210369931 date "2021-09-03" @default.
- W4210369931 modified "2023-09-26" @default.
- W4210369931 title "Differential expression of syncoilin, intermediate filament protein in human epithelial ovarian cancer." @default.
- W4210369931 doi "https://doi.org/10.31219/osf.io/8b4rw" @default.
- W4210369931 hasPublicationYear "2021" @default.
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