Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210369933> ?p ?o ?g. }
- W4210369933 endingPage "2111784" @default.
- W4210369933 startingPage "2111784" @default.
- W4210369933 abstract "The immunosuppression and immune escape of current immunotherapy result in low efficacy, and ferroptosis is greatly restricted by the low reactive oxygen species (ROS) production efficiency. Here, for the first time a “closed-loop” therapy based on photothermal enhancement of ferroptosis and immunotherapy stimulated by each other on a multifunctional nanoplatform is reported. This platform is composed of copper silicate and iron silicate mesoporous hollow nanospheres, followed by in situ growth of Au nanoparticles and loading of an immune adjuvant resiquimod R848. The laser irradiation-mediated heat and the introduction of copper ions significantly enhance ROS generation, leading to the simultaneous depletion of glutathione peroxidase 4 (GPX4) and glutathione (GSH). The onset of ferroptosis in tumor cells is thus enhanced and an immune response with immunogenic cell death (ICD) is triggered, promoting the dendritic cells (DCs) maturation and T cell infiltration. Interferon γ (IFN-γ) released from CD8+ T cells downregulates the expression of SLC7A11 and GPX4, which in turn enhances ferroptosis expression, thus constituting a “closed-Loop” therapy. Importantly, this system is effective in both killing the primary tumor and inhibiting tumor metastasis. The proposed “closed-loop” therapeutic strategy may provide a guidance for the design of future antitumor nanoplatforms." @default.
- W4210369933 created "2022-02-08" @default.
- W4210369933 creator A5027292194 @default.
- W4210369933 creator A5045143224 @default.
- W4210369933 creator A5046349034 @default.
- W4210369933 creator A5053073090 @default.
- W4210369933 creator A5061102034 @default.
- W4210369933 creator A5062571272 @default.
- W4210369933 creator A5065037360 @default.
- W4210369933 creator A5065223693 @default.
- W4210369933 creator A5073722575 @default.
- W4210369933 creator A5075350471 @default.
- W4210369933 date "2022-02-01" @default.
- W4210369933 modified "2023-10-16" @default.
- W4210369933 title "A “Closed‐Loop” Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy" @default.
- W4210369933 cites W1978178835 @default.
- W4210369933 cites W1997183854 @default.
- W4210369933 cites W2002490399 @default.
- W4210369933 cites W2023812730 @default.
- W4210369933 cites W2315185034 @default.
- W4210369933 cites W2339396284 @default.
- W4210369933 cites W2427645657 @default.
- W4210369933 cites W2536322725 @default.
- W4210369933 cites W2549188196 @default.
- W4210369933 cites W2606734676 @default.
- W4210369933 cites W2727828415 @default.
- W4210369933 cites W2763729073 @default.
- W4210369933 cites W2767055857 @default.
- W4210369933 cites W2799753096 @default.
- W4210369933 cites W2800103955 @default.
- W4210369933 cites W2800980552 @default.
- W4210369933 cites W2804447831 @default.
- W4210369933 cites W2807602551 @default.
- W4210369933 cites W2890597423 @default.
- W4210369933 cites W2913303535 @default.
- W4210369933 cites W2923485026 @default.
- W4210369933 cites W2942989512 @default.
- W4210369933 cites W2943793201 @default.
- W4210369933 cites W2954483872 @default.
- W4210369933 cites W2955284497 @default.
- W4210369933 cites W2964325900 @default.
- W4210369933 cites W2965253935 @default.
- W4210369933 cites W2969503538 @default.
- W4210369933 cites W2978688118 @default.
- W4210369933 cites W2980472864 @default.
- W4210369933 cites W2998894439 @default.
- W4210369933 cites W3002084570 @default.
- W4210369933 cites W3006101076 @default.
- W4210369933 cites W3010811731 @default.
- W4210369933 cites W3010991709 @default.
- W4210369933 cites W3016199768 @default.
- W4210369933 cites W3019038073 @default.
- W4210369933 cites W3021456386 @default.
- W4210369933 cites W3038476694 @default.
- W4210369933 cites W3043484583 @default.
- W4210369933 cites W3047874793 @default.
- W4210369933 cites W3047971458 @default.
- W4210369933 cites W3048369596 @default.
- W4210369933 cites W3084621691 @default.
- W4210369933 cites W3086396309 @default.
- W4210369933 cites W3092302767 @default.
- W4210369933 cites W3093281616 @default.
- W4210369933 cites W3093795255 @default.
- W4210369933 cites W3095034983 @default.
- W4210369933 cites W3096524591 @default.
- W4210369933 cites W3096886301 @default.
- W4210369933 cites W3108493784 @default.
- W4210369933 cites W3108735200 @default.
- W4210369933 cites W3109134796 @default.
- W4210369933 cites W3109801031 @default.
- W4210369933 cites W3112311946 @default.
- W4210369933 cites W3112558747 @default.
- W4210369933 cites W3112599058 @default.
- W4210369933 cites W3112671848 @default.
- W4210369933 cites W3120903220 @default.
- W4210369933 cites W3122102409 @default.
- W4210369933 cites W3126342703 @default.
- W4210369933 cites W3129581908 @default.
- W4210369933 cites W3133823534 @default.
- W4210369933 cites W3148143207 @default.
- W4210369933 cites W3151350205 @default.
- W4210369933 cites W3154124516 @default.
- W4210369933 cites W3164856578 @default.
- W4210369933 cites W3169075832 @default.
- W4210369933 cites W3172098401 @default.
- W4210369933 cites W3175275490 @default.
- W4210369933 cites W3181345198 @default.
- W4210369933 cites W3182406641 @default.
- W4210369933 cites W3196902013 @default.
- W4210369933 cites W4211179700 @default.
- W4210369933 cites W4231457728 @default.
- W4210369933 doi "https://doi.org/10.1002/adfm.202111784" @default.
- W4210369933 hasPublicationYear "2022" @default.
- W4210369933 type Work @default.
- W4210369933 citedByCount "68" @default.
- W4210369933 countsByYear W42103699332022 @default.
- W4210369933 countsByYear W42103699332023 @default.
- W4210369933 crossrefType "journal-article" @default.