Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210369996> ?p ?o ?g. }
- W4210369996 endingPage "794" @default.
- W4210369996 startingPage "794" @default.
- W4210369996 abstract "We performed a systematic review and meta-analysis of the treatment efficacy of immune checkpoint inhibitors (ICIs) in advanced/metastatic neuroendocrine neoplasms (NENs). MEDLINE and EMBASE were searched to identify studies that provide data on treatment response and/or survival outcomes of advanced/metastatic NEN patients treated with ICIs. The overall response rate (ORR) was pooled using a random-effects model. Meta-regression was performed to explore factors influencing the ORR. Individual patient data (IPD) meta-analysis of survival was performed using stratified Cox regression. Ten studies (464 patients) were included. The overall pooled ORR was 15.5% (95% confidence interval (CI), 9.5-24.3%), and it varied according to the primary site (thoracic, 24.7%; gastro-entero-pancreatic, 9.5%), tumor differentiation (poorly differentiated, 22.7%; well-differentiated, 10.4%), and drug regimen (combination, 25.3%; monotherapy, 10.1%). All these variables significantly influenced the ORR. Tumor differentiation was associated with both overall survival and progression-free survival (hazard ratio of poorly differentiated tumors, 4.2 (95% CI, 2.0-8.7) and 2.6 (95% CI, 1.6-4.4), respectively). Thus, the treatment efficacy of ICIs for advanced/metastatic NENs varied according to primary site, tumor differentiation, and drug regimen. Poorly differentiated NENs showed a better ORR than well-differentiated NENs but had a negative impact on survival." @default.
- W4210369996 created "2022-02-08" @default.
- W4210369996 creator A5000724784 @default.
- W4210369996 creator A5007506402 @default.
- W4210369996 creator A5030527374 @default.
- W4210369996 creator A5047471493 @default.
- W4210369996 creator A5049999297 @default.
- W4210369996 creator A5070044404 @default.
- W4210369996 creator A5085343772 @default.
- W4210369996 creator A5090754319 @default.
- W4210369996 date "2022-02-04" @default.
- W4210369996 modified "2023-09-26" @default.
- W4210369996 title "Efficacy of Immune Checkpoint Inhibitors against Advanced or Metastatic Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis" @default.
- W4210369996 cites W1575433014 @default.
- W4210369996 cites W1953677527 @default.
- W4210369996 cites W1973610279 @default.
- W4210369996 cites W1982967337 @default.
- W4210369996 cites W1986676815 @default.
- W4210369996 cites W2007872832 @default.
- W4210369996 cites W2019607817 @default.
- W4210369996 cites W2029984578 @default.
- W4210369996 cites W2050118439 @default.
- W4210369996 cites W2074146123 @default.
- W4210369996 cites W2093053044 @default.
- W4210369996 cites W2107328434 @default.
- W4210369996 cites W2111722073 @default.
- W4210369996 cites W2120959053 @default.
- W4210369996 cites W2125435699 @default.
- W4210369996 cites W2149214723 @default.
- W4210369996 cites W2161676563 @default.
- W4210369996 cites W2163703503 @default.
- W4210369996 cites W2164730570 @default.
- W4210369996 cites W2227093581 @default.
- W4210369996 cites W2296064806 @default.
- W4210369996 cites W2296591343 @default.
- W4210369996 cites W2531269403 @default.
- W4210369996 cites W2569525929 @default.
- W4210369996 cites W2608160487 @default.
- W4210369996 cites W2783897381 @default.
- W4210369996 cites W2785465457 @default.
- W4210369996 cites W2888018398 @default.
- W4210369996 cites W2891062388 @default.
- W4210369996 cites W2892095332 @default.
- W4210369996 cites W2893960509 @default.
- W4210369996 cites W2909679049 @default.
- W4210369996 cites W2912003477 @default.
- W4210369996 cites W2912485050 @default.
- W4210369996 cites W2988290606 @default.
- W4210369996 cites W2988416566 @default.
- W4210369996 cites W3002637272 @default.
- W4210369996 cites W3002973089 @default.
- W4210369996 cites W3008867012 @default.
- W4210369996 cites W3009875356 @default.
- W4210369996 cites W3010839046 @default.
- W4210369996 cites W3011291097 @default.
- W4210369996 cites W3013205517 @default.
- W4210369996 cites W3015529215 @default.
- W4210369996 cites W3016349309 @default.
- W4210369996 cites W3035208766 @default.
- W4210369996 cites W3106273722 @default.
- W4210369996 cites W3116399982 @default.
- W4210369996 cites W3126018719 @default.
- W4210369996 cites W3128478875 @default.
- W4210369996 cites W3137168371 @default.
- W4210369996 cites W3139498914 @default.
- W4210369996 cites W3155290342 @default.
- W4210369996 cites W3157076486 @default.
- W4210369996 cites W3160828487 @default.
- W4210369996 cites W4225291722 @default.
- W4210369996 cites W4245135890 @default.
- W4210369996 cites W78649709 @default.
- W4210369996 doi "https://doi.org/10.3390/cancers14030794" @default.
- W4210369996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35159061" @default.
- W4210369996 hasPublicationYear "2022" @default.
- W4210369996 type Work @default.
- W4210369996 citedByCount "6" @default.
- W4210369996 countsByYear W42103699962022 @default.
- W4210369996 countsByYear W42103699962023 @default.
- W4210369996 crossrefType "journal-article" @default.
- W4210369996 hasAuthorship W4210369996A5000724784 @default.
- W4210369996 hasAuthorship W4210369996A5007506402 @default.
- W4210369996 hasAuthorship W4210369996A5030527374 @default.
- W4210369996 hasAuthorship W4210369996A5047471493 @default.
- W4210369996 hasAuthorship W4210369996A5049999297 @default.
- W4210369996 hasAuthorship W4210369996A5070044404 @default.
- W4210369996 hasAuthorship W4210369996A5085343772 @default.
- W4210369996 hasAuthorship W4210369996A5090754319 @default.
- W4210369996 hasBestOaLocation W42103699961 @default.
- W4210369996 hasConcept C126322002 @default.
- W4210369996 hasConcept C143998085 @default.
- W4210369996 hasConcept C207103383 @default.
- W4210369996 hasConcept C2779066768 @default.
- W4210369996 hasConcept C2781413609 @default.
- W4210369996 hasConcept C44249647 @default.
- W4210369996 hasConcept C50382708 @default.
- W4210369996 hasConcept C71924100 @default.
- W4210369996 hasConcept C95190672 @default.
- W4210369996 hasConceptScore W4210369996C126322002 @default.