FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210373571> ?p ?o ?g. }

• W4210373571 abstract "Abstract Background A comprehensive understanding of the molecular mechanisms of adipogenesis is a critically important strategy for identifying new targets for obesity intervention. Methods Transcriptomic and lipidomic approaches were used to explore the functional genes regulating adipogenic differentiation and their potential mechanism of action in OP9 cells and adipose-derived stem cells. Oil Red O staining was used to detect oil droplets in adipocytes. Results RNA sequencing (RNA-seq) showed that Slc25a5 expression was significantly upregulated in adipogenic differentiation. Depletion of Slc25a5 led to the suppressed expression of adipogenesis-related genes, reduced the accumulation of triglycerides, and inhibited PPARγ protein expression. Moreover, the knockdown of Slc25a5 resulted in significant reduction of oxidative phosphorylation (OXPHOS) protein expression (ATP5A1, CQCRC2, and MTCO1) and ATP production. The RNA-seq and real-time quantitative polymerase chain reaction (RT–qPCR) results suggested that adipogenic differentiation is possibly mediated by ERK1/2 phosphorylation, and this hypothesis was confirmed by intervention with PD98059 (an ERK 1/2 inhibitor). Conclusions This study indicates that Slc25a5 inhibits adipogenesis and might be a new therapeutic target for the treatment of obesity." @default.
• W4210373571 created "2022-02-08" @default.
• W4210373571 creator A5040298811 @default.
• W4210373571 creator A5046597133 @default.
• W4210373571 creator A5058629921 @default.
• W4210373571 creator A5071878141 @default.
• W4210373571 creator A5086916644 @default.
• W4210373571 creator A5088905478 @default.
• W4210373571 date "2022-02-02" @default.
• W4210373571 modified "2023-10-16" @default.
• W4210373571 title "Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells" @default.
• W4210373571 cites W2026863186 @default.
• W4210373571 cites W2039019428 @default.
• W4210373571 cites W2066447432 @default.
• W4210373571 cites W2067870508 @default.
• W4210373571 cites W2092016612 @default.
• W4210373571 cites W2104085328 @default.
• W4210373571 cites W2135778926 @default.
• W4210373571 cites W2150621637 @default.
• W4210373571 cites W2167376541 @default.
• W4210373571 cites W2173681478 @default.
• W4210373571 cites W2283068534 @default.
• W4210373571 cites W2344921005 @default.
• W4210373571 cites W2519479884 @default.
• W4210373571 cites W2575562187 @default.
• W4210373571 cites W2602770386 @default.
• W4210373571 cites W2766120686 @default.
• W4210373571 cites W2901847109 @default.
• W4210373571 cites W2921972886 @default.
• W4210373571 cites W2964463455 @default.
• W4210373571 cites W2978642359 @default.
• W4210373571 cites W3002920254 @default.
• W4210373571 cites W3012183334 @default.
• W4210373571 cites W3213973231 @default.
• W4210373571 cites W4200017855 @default.
• W4210373571 cites W4200149700 @default.
• W4210373571 doi "https://doi.org/10.1186/s11658-022-00314-y" @default.
• W4210373571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35109789" @default.
• W4210373571 hasPublicationYear "2022" @default.
• W4210373571 type Work @default.
• W4210373571 citedByCount "11" @default.
• W4210373571 countsByYear W42103735712021 @default.
• W4210373571 countsByYear W42103735712022 @default.
• W4210373571 countsByYear W42103735712023 @default.
• W4210373571 crossrefType "journal-article" @default.
• W4210373571 hasAuthorship W4210373571A5040298811 @default.
• W4210373571 hasAuthorship W4210373571A5046597133 @default.
• W4210373571 hasAuthorship W4210373571A5058629921 @default.
• W4210373571 hasAuthorship W4210373571A5071878141 @default.
• W4210373571 hasAuthorship W4210373571A5086916644 @default.
• W4210373571 hasAuthorship W4210373571A5088905478 @default.
• W4210373571 hasBestOaLocation W42103735711 @default.
• W4210373571 hasConcept C104317684 @default.
• W4210373571 hasConcept C11960822 @default.
• W4210373571 hasConcept C122927707 @default.
• W4210373571 hasConcept C127561419 @default.
• W4210373571 hasConcept C150194340 @default.
• W4210373571 hasConcept C162317418 @default.
• W4210373571 hasConcept C171089720 @default.
• W4210373571 hasConcept C173396325 @default.
• W4210373571 hasConcept C185592680 @default.
• W4210373571 hasConcept C2780806160 @default.
• W4210373571 hasConcept C55493867 @default.
• W4210373571 hasConcept C57074206 @default.
• W4210373571 hasConcept C57600042 @default.
• W4210373571 hasConcept C67705224 @default.
• W4210373571 hasConcept C86803240 @default.
• W4210373571 hasConcept C95444343 @default.
• W4210373571 hasConcept C97029542 @default.
• W4210373571 hasConceptScore W4210373571C104317684 @default.
• W4210373571 hasConceptScore W4210373571C11960822 @default.
• W4210373571 hasConceptScore W4210373571C122927707 @default.
• W4210373571 hasConceptScore W4210373571C127561419 @default.
• W4210373571 hasConceptScore W4210373571C150194340 @default.
• W4210373571 hasConceptScore W4210373571C162317418 @default.
• W4210373571 hasConceptScore W4210373571C171089720 @default.
• W4210373571 hasConceptScore W4210373571C173396325 @default.
• W4210373571 hasConceptScore W4210373571C185592680 @default.
• W4210373571 hasConceptScore W4210373571C2780806160 @default.
• W4210373571 hasConceptScore W4210373571C55493867 @default.
• W4210373571 hasConceptScore W4210373571C57074206 @default.
• W4210373571 hasConceptScore W4210373571C57600042 @default.
• W4210373571 hasConceptScore W4210373571C67705224 @default.
• W4210373571 hasConceptScore W4210373571C86803240 @default.
• W4210373571 hasConceptScore W4210373571C95444343 @default.
• W4210373571 hasConceptScore W4210373571C97029542 @default.
• W4210373571 hasFunder F4320321001 @default.
• W4210373571 hasFunder F4320335787 @default.
• W4210373571 hasIssue "1" @default.
• W4210373571 hasLocation W42103735711 @default.
• W4210373571 hasLocation W42103735712 @default.
• W4210373571 hasLocation W42103735713 @default.
• W4210373571 hasOpenAccess W4210373571 @default.
• W4210373571 hasPrimaryLocation W42103735711 @default.
• W4210373571 hasRelatedWork W184720341 @default.
• W4210373571 hasRelatedWork W2037960158 @default.
• W4210373571 hasRelatedWork W2083667486 @default.
• W4210373571 hasRelatedWork W2365725855 @default.
• W4210373571 hasRelatedWork W2373924277 @default.
• W4210373571 hasRelatedWork W2537626199 @default.

• next