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• W4210380416 startingPage "1475" @default.
• W4210380416 abstract "Human papillomavirus (HPV) is a significant risk factor for head and neck squamous cell carcinoma (HNSCC). HPV+ HNSCC patients have a higher survival rate, which may be related to its unique tumor microenvironment. Exosomes are emerging as a communication tool between tumor cells and the tumor microenvironment, including cancer-associated fibroblasts (CAFs). In this study, 111 clinical samples tissues and public sequencing data were analyzed. Our study found fewer CAFs infiltrated in HPV+ HNSCC, and poor CAF infiltration level was associated with a good prognosis. HPV+ HNSCC cell-derived exosomes can significantly reduce the phenotypic transformation of fibroblasts. miR-9-5p, as a miRNA enriched in HPV+ HNSCC cell-derived exosomes, can be transferred to fibroblasts. miR-9-5p mimic transfection decreased the expression of NOX4 and the level of intracellular reactive oxygen species (ROS), which inhibited the transforming growth factor beta 1(TGF-β1)-induced increase of αSMA levels. Therefore, these results indicated that HPV+ HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4, which is related to the excellent prognosis of HPV patients." @default.
• W4210380416 created "2022-02-08" @default.
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• W4210380416 date "2022-03-03" @default.
• W4210380416 modified "2023-09-30" @default.
• W4210380416 title "HPV⁺ HNSCC‐derived exosomal miR‐9‐5p inhibits TGF‐β signaling‐mediated fibroblast phenotypic transformation through NOX4" @default.
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• W4210380416 doi "https://doi.org/10.1111/cas.15281" @default.
• W4210380416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35100464" @default.
• W4210380416 hasPublicationYear "2022" @default.
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